癌基因C-myc在实验性大鼠肝癌变过程中的表达  

A STUDY OF EXPRESSION OF C-myc IN EXPERIMENTAL PRECANCEROUS LESION OF LIVER RATS

作　　者：施公胜[1] 韩新华[1] 王淼[1] 顾美珍[1] 黄剑飞[1] 曹翔[1] 孙超[1] 

机构地区：[1]南通医学院附属医院病理科,南通226001

出　　处：《南通医学院学报》2000年第2期148-149,共2页ACTA Academiae Medicinae Nantong

摘　　要：目的 :探讨癌基因 C-myc产物在实验性大鼠肝癌变过程中作用。方法 :应用 C-myc癌基因蛋白单克隆抗体 ,采用免疫组化 SP方法 ,检测分析大鼠肝癌变过程中 C-myc蛋白表达。结果 :诱癌早期增生的肝细胞及变异肝细胞灶中即显示 C-myc的过度表达 ,并随增生肝细胞结节的形成和演进所表达的细胞也增多。结论 :癌基因 C-myc激活后其产物超量表达参与了实验性肝癌的发生和发展 。Objective:To study the effect of C-myc oncogene protein in precancerous lesions of liver of rat.Method: The expression of C-myc oncogene protein was examined with the monoclonal antibody of C-myc and immunohistochemical S-P method in precancerous lesions of liver in rat. Result : The results showed that overexpression of C-myc was presented in the proliferated hepatocytes foci during the early stage of hepatocarcinogenesis and with the formation and progression of hyperplastic hepatocytic nodules , the overexpression cells increased . Conclusion : The overexpression of C-myc oncogene was directly involved in the initiation and progression of hepatocarcinoma in rat and could be used as a consultative marker for early diagnosis of human hepatocarcinoma. [

关 键 词：癌基因蛋白 癌前病变 肝癌 C-MYC 

分 类 号：R735.702[医药卫生—肿瘤] R730.21[医药卫生—临床医学]