盐酸法舒地尔治疗急性脑梗死47例疗效观察  

Observation of curative effect of Fasudil hydrochloride on acute cerebral infarction

作　　者：张力 赵立杰 王晓鹏[2] 李敏娟 赵卓华 魏建华 

机构地区：[1]河北省赵县人民医院内三科,河北赵县051530 [2]河北医科大学第二医院神经内科,河北石家庄050000

出　　处：《河北中医》2012年第3期474-476,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察盐酸法舒地尔治疗急性脑梗死的临床疗效。方法将92例急性脑梗死患者随机分为2组。治疗组47例在常规治疗基础上加用盐酸法舒地尔注射液,对照组45例在常规治疗基础上加用丹红注射液。2组均14 d为1个疗程,1个疗程后观察2组神经功能缺损评分(NDS)和临床疗效。结果治疗组治疗后NDS明显改善(P<0.05),与对照组比较差异有统计学意义(P<0.05);治疗组总有效率78.72%,对照组总有效率55.56%,2组比较差异有统计学意义(P<0.05)。结论盐酸法舒地尔可以改善急性脑梗死患者的神经功能缺损,提高疗效。Objective To observe the curative effect of Fasudil hydrochloride on acute cerebral infarction.Methods 92 cases of acute cerebral infarction were randomly divided into two groups.Treatment group（n=47） received combination of routine therapy and Fasudil hydrochloride.Control group（n=45） received combination of routine therapy and Danhong injection.The course was 14 days in two groups.Neurologic Deficit Scale（NDS） and clinical effect were observed after a course.Results The NDS in treatment group was significantly improved after treatment.There was significant difference between two groups（P0.05）.The total effective rate in treatment group（78.72%） was higher than that in control group（55.56%,P0.05）.Conclusion Fasudil hydrochloride can improve neurological impairment of patients with acute cerebral infarction,and increase curative effect.

关 键 词：1-(5-异喹啉磺酰基)-2-甲基哌嗪 类似物和衍生物 急性病 脑梗死 血管舒张药 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R743.330.53[医药卫生—临床医学]