CGEONA对荷LA-795肺腺癌小鼠和正常小鼠放射敏感性的影响  

Effect of CGEONA on radiosensitivity in LA-795 pulmonary adenocarcinoma-bearing mice and normal mice\

作　　者：胡璧[1] 沈瑜[1] 周则卫[1] 王争[1] 张荷清[1] 

机构地区：[1]中国医学科学院

出　　处：《中华放射医学与防护杂志》2000年第2期77-79,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金!3 93 70 2 2 6

摘　　要：目的　为了寻找低毒有效的放射增敏剂 ,观察CGEONA(羧基 苯乙烯基锗倍半氧化物钠盐 )对荷瘤小鼠和正常小鼠放射敏感性的影响。方法　放射增敏实验用T 73 9小鼠 ,肿瘤模型LA 795肺腺癌 ,采用肿瘤再生长延缓法评价效果 ;放射防护实验用昆明种小鼠 ,观察 3 0d存活率和对造血系统的影响。结果　CGEONA药物浓度为 1/ 10LD50 时平均放射增敏比为 1 4。放射防护实验给药组与对照组相比 ,存活率以及造血系统指标无明显差异。结论　CGEONA是新型低毒有效放射增敏剂 ,对照射的正常动物无放射增敏作用 ,值得进一步研究。Objective\ In search for less toxic and more effective radiosensitizer.The effects of CGEONA (carboxy\| β \|phenyl\|vinyl\|germanium sesquioxide sodium salt) on radiosensitivity in tumor\|bearing mice and normal mice were investigated. Methods Radiosensitization experiments were performed on T\|739 mice.tumor model was LA\|795 pulmonary adenocarcinoma and tumor response was assessed using a regtowth delay.Radioprotection experiments were performed on Kunming mice. The 30\|day survival rate and effect on hemopoietic system were observed. Results The average sensitization enhancement ratio of CGEONA was 1.4 using 1/10 LD 50 drug dose.The radioprotection experiments showed no significant difference between treated mice and control mice for survival rate and hemopoietic systcm. Conclusion CGEONA shows great potential as a new type radiosensitizer with less toxicity and more effectiveness. It has no radiosensitizing effect on normal mice and is worthy of further studies.\;

关 键 词：肺腺癌 肺肿瘤 放射增敏剂 CGEONA 

分 类 号：R730.55[医药卫生—肿瘤]