Selective impairment in recognizing the familiarity of self faces in schizophrenia  

作　　者：ZHANG Lin ZHU Hong XU Miao JIA HongXiao LIU Jia 

机构地区：[1]State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100875,China [2]Beijing Anding Hospital,Capital Medical University,Beijing 100088,China [3]Graduate University of the Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Science Bulletin》2012年第15期1818-1823,共6页

基　　金：supported by the 100 Talents Program of the Chinese Academy of Sciences;the National Natural Science Foundation of China (91132703);the National Basic Research Program of China(2010CB833903, 2011CB505402);the China Postdoctoral Science Foundation (20060400367);the Fundamental Research Funds for Central Universities

摘　　要：The concept of self is a fundamental characteristic of the human mind,and the alteration of self is thought to be a core deficit of schizophrenia.Previous studies have demonstrated that patients with schizophrenia are deficient in self-face recognition.Because self faces are not only self-related but also highly familiar,it is unclear whether such deficit arises from the breakdown of the self-awareness or the failure of recognizing the familiarity of self faces.Here we directly tested these two alternatives by instructing patients with schizophrenia to recognize the identity of a morphed face created by blending face features between any of two identities from the self face,a familiar face,and a novel face.We found that there was no association between the recognition of the self and the recognition of the familiarity,suggesting these two component processes are independent in schizophrenia.Further,patients with schizophrenia were significantly worse in recognizing the familiarity of faces than normal participants,whereas no difference in the sense of self was found between the two groups.Taken together,our finding suggests that it is the sense of familiarity,not the sense of self,that is selectively impaired in self-face recognition in schizophrenia.Thus,our study challenges the hypothesis that the deficit in self-face recognition in schizophrenia reflects the breakdown of self-awareness.The concept of self is a fundamental characteristic of the human mind, and the alteration of self is thought to be a core deficit of schizophrenia. Previous studies have demonstrated that patients with schizophrenia are deficient in self-face recognition. Because self faces are not only self-related but also highly familiar, it is unclear whether such deficit arises from the breakdown of the self-awareness or the failure of recognizing the familiarity of self faces. Here we directly tested these two alternatives by instructing patients with schizophrenia to recognize the identity of a morphed face created by blending face features between any of two identities from the self face, a familiar face, and a novel face. We found that there was no association between the recognition of the self and the recognition of the familiarity, suggesting these two component processes are independent in schizophrenia. Further, patients with schizophrenia were significantly worse in recognizing the familiarity of faces than normal participants, whereas no difference in the sense of self was found between the two groups. Taken together, our finding suggests that it is the sense of familiarity, not the sense of self, that is selectively impaired in self-face recognition in schizophrenia. Thus, our study challenges the hypothesis that the deficit in self-face recognition in schizophrenia reflects the breakdown of self-awareness.

关 键 词：精神分裂症 面孔识别 自我意识 面部特征 直接测试 特征和 患者 参与者 

分 类 号：R749.3[医药卫生—神经病学与精神病学]