p16蛋白在乳腺癌中的表达及其临床意义  

Expression of p16 Protein and its Significance in Breast Benign Diseases and Breast Cancer

作　　者：丁志杰[1] 齐春莲[1] 袁媛[1] 高华[1] 

机构地区：[1]中国医科大学肿瘤研究所,沈阳110001

出　　处：《中国医科大学学报》2000年第2期112-114,共3页Journal of China Medical University

摘　　要：目的 :探讨肿瘤抑制基因 MTS1的产物 p16蛋白在乳腺癌 ,乳腺良性疾病中的表达及其临床意义。方法 :采用 S- P免疫组织化学方法 ,检测 p16蛋白在 30例乳腺良性疾病及 5 0例乳腺癌中的表达。结果 :p16蛋白在乳腺良性疾病中 10 0 %高强度表达 ,在乳腺癌中仅有 5 0 %阳性表达率 ,且表达强度低。p16蛋白表达与乳腺癌的组织学分级、TNM分期、淋巴结转移及预后有关。结论 :MTS1基因在抑制乳腺癌的发生发展过程中可能起重要作用。p16蛋白可作为乳腺癌的一种新的标志物。Objective:The purpose of this paper was to investigate the expression of p16 in breast cancer and its significance. Methods:By using S P immunohistochemical staining technique, we studied 30 cases of breast benign diseases and 50 cases of primary breast cancers. Results:All benign specimens showed high level of p16 with strong staining, only 50% showed weak positive staining of p16 in breast cancer. Abnormal expression of p16 were correlated with several histological parameters, such as histological grading, TNM staging lymphnode meta stasis and clinical prognosis. Conclusion: MTS1 gene abnormalities may play a significant role in breast cancer progression. p16 might be a new marker of breast cancer.

关 键 词：P16蛋白 乳腺癌 基因表达 

分 类 号：R737.9[医药卫生—肿瘤]