低氧放疗对荷瘤小鼠肝脏丙二醛含量的影响  

The Effect of Hypoxyradiotherapy on MDA in Livers of Tumor-bearing Mice

作　　者：冯忠令[1] 李彦敏[1] 奚奇[2] 张银娟[1] 刘意[1] 

机构地区：[1]中国医科大学第一临床学院放疗科,沈阳110001 [2]中国医科大学预防医学系毒理教研室

出　　处：《中国医科大学学报》2000年第2期145-146,共2页Journal of China Medical University

摘　　要：目的 :研究低氧放疗对荷瘤小鼠肝脏丙二醛 (malondialhehyde,MDA)含量的影响。方法 :用 TBA法检测荷肉瘤 S1 80 的 Balb/ c纯系小鼠在低氧条件下 (呼吸 10 .5 % O2 混合气体 )照射后肝脏 MDA含量变化。结果 :不同治疗方法处理动物后第 7、14d低氧放射组的肝脏 MDA含量明显低于单纯放射组与单纯低氧组 P <0 .0 5。结论 :低氧放疗可以降低荷瘤宿主肝脏 MDA含量 ,可能对肝脏具有放射防护作用。Objective: The experiment was designed to study the contents of malondialhehyde (MDA) in host livers of sarcoma 180 bearing mice after hypoxyradiotherapy. Methods: The contents of MDA were studied in Balb/c sarcoma 180 bearing mice by TBA method after breathing 10.5% oxygen during radiotherapy. Results: The contents of MDA were significantly lower in livers in hypoxyradiotherapy group than those in the control group on the 7 th and 14 th day after radiotherapy (P<0.05). Conclusion: Hypoxyradiotherapy can decrease MDA contents in host livers and preserve normal tissues.

关 键 词：肝脏丙二醛 肉瘤S180 放射疗法 低氧放疗 

分 类 号：R730.55[医药卫生—肿瘤]