Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis  

作　　者：Yanbo Liu Chunming Miao Zhenjiang Wang Xin He Weigao Shen 

机构地区：[1]Beihua University Faculty of Medicine,Jilin 132013,Jilin Province,China

出　　处：《Neural Regeneration Research》2012年第12期924-931,共8页中国神经再生研究（英文版）

基　　金：supported by the Natural Science Foundation of Jilin Province,No.2011146,2012150;the Natural Science Foundation of Jilin Technology Division,No.201133139 and 201032235

摘　　要：A survivin small interfering RNA sequence specific for a human and mouse homogenous sequenc~ was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.A survivin small interfering RNA sequence specific for a human and mouse homogenous sequenc~ was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.

关 键 词：RNA interference SURVIVIN GLIOBLASTOMA APOPTOSIS 

分 类 号：Q255[生物学—细胞生物学] Q756