原发性胆汁性肝硬化免疫分子机制研究进展  

Research progress of immunological and molecular mechanism of primary biliary cirrhosis

作　　者：尤玉琴 孔祥平 

机构地区：[1]解放军第四五八医院全军肝病中心,广州510600

出　　处：《传染病信息》2012年第2期126-128,共3页Infectious Disease Information

基　　金：国家重点基础研究发展计划(973计划)(2010CB945502)

摘　　要：原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)是一种免疫介导损伤胆管上皮细胞及肝内小胆管的胆汁淤积性自身免疫性肝病,具有发展为肝硬化的倾向。多种免疫相关基因通过影响疾病易感性、免疫调节等途径,促使PBC的发生、发展。本文就PBC的免疫分子机制研究动态进行综述。Primary biliary cirrhosis （PBC） is an autoimmune cholestatic liver disease in which an immune-mediated injury tar- gets bile duct epithelial cells and small intrahepatie bile ducts. It has a tendency to develop liver cirrhosis. Various immune-related genes promote the occurrence and development of PBC by affecting the susceptibility of the disease and immune regulation. This re- view focuses on the research dynamics of immunological and molecular mechanisms of PBC.

关 键 词：肝硬化 胆汁性 自身免疫 分子生物学 

分 类 号：R575.22[医药卫生—消化系统]