百草枯中毒早期含漱地塞米松对降低口腔粘膜损伤的影响  

Effect of Reducing Oral Mucosal Injury by Gargling Dexamethasone at Early Paraquat Poisoning

作　　者：黄柳清[1] 肖生翠[1] 陈瑰荣[1] 

机构地区：[1]广东医学院附属医院消化内科,湛江524001

出　　处：《齐齐哈尔医学院学报》2012年第6期709-710,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨百草枯中毒早期含漱地塞米松对降低口腔粘膜损伤的影响。方法将59例口服或口含百草枯急性中毒患者分为试验组(A组)30例和对照组(B组)29例。A组口腔护理给予地塞米松液含漱,B组按传统方法进行口腔护理;将试验A组30例又分为(A1组)15例和(A2组)15例。A1组为口服或口含百草枯后第1天开始含漱地塞米松,A2组为口服或口含百草枯后第2天开始含漱地塞米松。结果试验A组与对照B组口腔粘膜度损伤比较差异有非常大的显著性(P<0.0005);试验组的A1组与A2组口腔粘膜损伤比较差异有显著性(P<0.017)。结论口服或口含百草枯中毒早期含漱地塞米松能明显降低及减轻口腔粘膜损伤,且越早含漱效果越好。Objective To explore the effect of reducing oral mucosal injury by gargling dexamethasone at early Paraquat poisoning.Methods 59 cases of oral or sublingual acute paraquat poisoning patients were divided into test group（group A） of 30 cases and the control group（group B） of 29 cases.Group A was administered dexamethasone mouthwash as oral care,while group B was given oral care in traditional method and the 30 cases in group A were divided into group A1 and group A2,with 15 patients in each group.Group A1 gargled dexamethasone on the first day of their oral or sublingual paraquat poisoning,while group A2 gargled dexamethasone on the second day.Results oral mucosal injury of group A and group B had remarkable difference（P0.0005）;the injury of group A1 and group A2 in test group had significant difference（P0.017）.Conclusions Gargling dexamethasone at early Paraquat poisoning can evidently reduce and lessen oral mucosal injury,and the earlier the better..

关 键 词：百草枯中毒 地塞米松 降低 口腔粘膜 损伤 

分 类 号：R739.63[医药卫生—肿瘤]