FAK在胃癌转移中的研究进展  

Researches of FAK in the Metastasis of Gastric Garcinoma

作　　者：刘先伟[1] 苏国强[1] 

机构地区：[1]福建医科大学第一临床医学院,福建厦门361003

出　　处：《医学综述》2012年第8期1167-1170,共4页Medical Recapitulate

摘　　要：胃癌是消化系统常见的恶性肿瘤之一,针对恶性肿瘤的外科性手术的治疗策略已趋于成熟,但预后效果并不令人十分满意。局部黏着斑激酶(FAK)是一种非酪氨酸蛋白激酶受体,是细胞内多个信号转导的枢纽。FAK可能成为胃癌治疗的一个重要靶点,抑制FAK的功能可以阻断多条与肿瘤相关的信号通路。大量研究发现,FAK在肿瘤转移的过程中起着重要作用。现就FAK在胃癌的发生、侵袭和转移过程中的作用进行综述。The gastric cancer is one of the malignant tumors in digestive system,and the surgical strategy already tends to be mature.However the prognosis of gastric carcinoma does not make us satisfy.Focal adhension kinase（FAK）was recognized as a non tyrosine protein kinase receptor,a hub of many cell signal transductions.FAK may become a potential target in the therapy of stomach cancer.It has been reported that inhibiting the function of the FAK can block multiple signal paths which were associated with cancer.Many results of researches show that FAK plays a great importance in the gastric carcinoma metastasis.Here is to make a review on FAK roles in the genesis,invasion and metastasis of gastyic cancer.

关 键 词：胃癌 肿瘤转移 黏着斑激酶 

分 类 号：R735[医药卫生—肿瘤]