头部亚低温对脑出血患者炎性损伤干预作用的研究  

The effect of head mild hypothermia on inflammatory injury of intracerebral hemorrhage

作　　者：张鹏[1] 陈润青[1] 甄明清[1] 李梅[1] 杨友松[2] 

机构地区：[1]烟台经济技术开发区医院神经内科,264006 [2]四川省人民医院神经内科

出　　处：《中国实用医药》2012年第9期20-21,共2页China Practical Medicine

摘　　要：目的观察脑出血患者白细胞介素-1β(IL-1β)、细胞间粘附分子-1(ICAM-1)和肿瘤坏死因子-α(TNF-α)含量的变化及头部亚低温对其的影响。方法 86例脑出血患者根据是否加用头部亚低温治疗分为头部亚低温组(45例)和对照组(41例),采用酶联免疫吸附法(ELISA)测定两组患者治疗前及治疗后7d血清1L-1β、ICAM-1、TNF-α含量,并与正常组(30例)进行比较。结果头部亚低温组和对照组治疗前1L-1β、ICAM-1、TNF-α明显升高,与正常组比较差异均具有显著性(P<0.01);治疗前头部低温组和对照组间1L-1β、ICAM-1、TNF-α差异均无显著性(P>0.05);治疗后7d,头部亚低温组1L-1β、ICAM-1、TNF-α较治疗前明显降低(P<0.05),对照组降低不明显(P>0.05),头部亚低温组与对照组比较差异均具有显著性(P<0.01)。结论脑出血患者早期血清1L-1β、ICAM-1、TNF-α含量明显升高,头部亚低温组可有效降低其含量。Objective To study changes in interleukin-1β（1L-1β）,intercellular adhesion molecule-1（ICAM-1）and tumor necrosis factor-α（TNF-α）levels in intracerebral hemorrhage（ICH）and observe potential effect of head mild hypothermia.Methods Eighty-six cases of intracerebral hemorrhage（ICH）were divided into head mild hypothermia treatment group（n=45）and control group（n=41）according to treatment with or without head mild hypothermia.The serum 1L-1β,ICAM-1 and TNF-α level in the twe groups were determined on the 7 th days with enzyme linked immunoadsorbent assay（ELISA）,and compared to those of the healthy volunteers（n=30）.Results The serum 1L-1β,ICAM-1 and TNF-α level in both head mild hypothermia treatment group and control group were higher before treatment compared with the healthy controls（all P〈0.01）,and there was no significant difference in serum 1L-1β,ICAM-1 and TNF-α level before treatment between the head mild hypothermia and control group（both P〉0.05）.Serum 1L-1β,ICAM-1 and TNF-α level in the head mild hypothermia treatment group on the 7 th day after the head mild hypothermia were significantly lower than befor the head mild hypothermia treatment（P〈0.05）,while the changes of control group was not significant（P〉0.05）,and significant ifference in serum 1L-1β,ICAM-1 and TNF-α was found between head mild hypothermia treatment group and control group on the 7 th day（P〈0.01）.Conclusion The levels of serum 1L-1β,ICAM-1 and TNF-α were increased significantly during early stae of ICH.Head mild hypothermia can effectively reduce the serum 1L-1β,ICAM-1 and TNF-α levels of early ICH patients.

关 键 词：脑出血 头部亚低温 白细胞介素-1Β 细胞间粘附分子-1 肿瘤坏死因子-α 

分 类 号：R743.34[医药卫生—神经病学与精神病学]