三氧化二砷联合全反式维A酸治疗急性早幼粒细胞白血病疗效与安全性分析  

The effect and safety analysis of arsenic trioxide combined with all-trans retinoic acid in treatingpatients with acute promyelocytic leukemia

作　　者：任清宇[1] 赵可煜[1] 刘福莲[1] 陈素芳[1] 王振兴[1] 于静敏[1] 裴书方 

机构地区：[1]解放军第三七一中心医院肿瘤血液科,河南新乡453000

出　　处：《中国医师进修杂志》2012年第13期34-36,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的观察三氧化二砷（ATO）联合全反式维A酸（ATRA）治疗急性早幼粒细胞白血病（APL）的疗效与安全性。方法83例初治APL患者按随机数字表法分为两组，观察组48例采用ATO联合ATRA诱导缓解治疗，对照组35例采用ATRA联合化疗诱导治疗，比较两组的疗效及不良反应发生情况。结果观察组有效率和早期病死率分别为100．0％（48，48）和0，对照组分别为97．1％（34/35）和2．9％（1／35），两组比较差异无统计学意义（P〉0．05）。观察组骨髓抑制、感染、肝肾损害、心脏毒性和消化道症状发生率分别为8．3％（4148）、10．4％（5n8）、12．5％（6148）、6．2％（3，48）和18．8％（9／48），而对照组分别为97．1％（34／35）、65．7％（23，35）、45．7％（16／35）、37．1％（13，35）和100．0％（35／35），两组比较差异有统计学意义（P〈0．05）。结论ATO联合ATRA治疗APL，疗效显著，不良反应少，值得临床推广应用。Objective To observe the effect and safety of arsenic trioxide （ATO） combined with all-trans retinoic acid （ATRA） in treating patients with acute promyelocytic leukemia （APL）. Methods Eighty-three cases with APL treated for the first time were divided into two groups by random digits table method ： observation group with 48 cases was received combination induction treatment of ATO and ATRA, control group with 35 cases was treated with combination induction treatment of ATRA and chemotherapy. The clinical effect and adverse reaction between two groups were compared. Results The effective rate and early death rate were 100.0%（48/48 ） and 0 in observation group, 97.1% （34/35） and 2.9%（ 1/35 ） in control group,which had no significant difference between two groups （P 〉 0.05）. The incidences of bone marrow suppression,infection, hver and kidney damage,cardiac toxicity and gastrointestinal symptoms were 8.3% （4/48）, 10.4% （5/48）, 12.5% （6/48）,6.2% （3/48） and 18.8% （9/48） in observation group,while 97.1% （34/35）, 65.7% （23/35） ,45.7% （ 16/35 ） ,37.1% （ 13/35 ） and 100.0% （35/35） in eontrol group,which had significant differences between two groups （P 〈 0.05）. Conclusion Combination treatment of ATO and ATRA in APL has an obvious effect and few adverse reaction, which can be applied in clinic.

关 键 词：白血病 早幼粒细胞 急性 维甲酸 亚砷酸 

分 类 号：R733.71[医药卫生—肿瘤]