肝血管病变在乙肝肝硬化发展过程中的作用  

Survey on the role and significance of small interlobular blood vessles in liver cirrhosis

作　　者：张光曙[1] 陈崇兴[1] 徐传镇[1] 闫承玉 

机构地区：[1]中国人民解放军第88医院,山东泰安271000

出　　处：《泰山医学院学报》2000年第1期23-24,共2页Journal of Taishan Medical College

摘　　要：目的　肝硬化的形成一般认为是由纤维组织增生、胶原纤维合成增加所致 ,但肝内循环受阻 ,出现门脉高压的病因仍需探讨。方法　收集 85例肝硬化肝组织作HE、组化和免疫组化染色 ,镜检观察病变特点。结果　肝组织切片内除见一般肝硬化病理特点外 ,在门脉区内均可见到小血管内存在血栓和机化 ,并有明显炎细胞浸润血管 ,而且病变程度与临床分型诊断和病型轻重密切相关。结论　失代偿期肝硬化腹水形成除与肝内慢性炎症有关外 ,门脉区内小血管炎、栓塞和机化是其重要病因。Objective: Fibroplastic proliferation and increase of fibrinogenic synthesis are generally considered as the main pathogenesis of liver cirrhosis ,but the pathogenesis of ascitic fomation should be studied,too.Methods: 85 specimens of liver cirrhosis were collected for HE,hestochemical and immunochemical stains in order to study the characteristi changes.Results: It was found that there were thrombosis in small blood vessels ,proliferation of astral or arciform fibers in small vessels and inflammatory cell infiltration in interlobular vessels by HE,histochemical and immunohistochemical stains, and especially all these changes were in accordance with the severity of pathological change and clinical appearance.Conclusion: All these changes could play an important role in interfering the circulation in liver and couldn't be neglected in cliniceal treatment.

关 键 词：肝硬化 乙型肝炎 肝血管病变 

分 类 号：R575.2[医药卫生—消化系统]