老年癫痫病人的抗痫药浓度监测及诊治特点  

Serum levels of anti-epileptic drugs and treatment in the elderly patients

作　　者：张敬军[1] 夏作理[1] 俞丽云[2] 

机构地区：[1]泰山医学院附属医院微循环研究所,山东泰安271000 [2]上海医科大学华山医院,上海200040

出　　处：《泰山医学院学报》2000年第1期27-28,共2页Journal of Taishan Medical College

摘　　要：目的　探讨老年癫痫病人的抗痫药浓度变化及诊治特点。方法　用HPLC方法或TDX分析仪测定血浓度。结果　老年性癫痫多为症状性癫痫 ,全身性发作的疗效优于部分性发作。服常规剂量 ,苯妥英钠、卡马西平及丙戊酸钠的血浓度范围分别为 :12 .1～ 5 1μg·ml- 1 ,3.5 4～ 15 .1μg·ml- 1 ,2 8～ 12 7μg·ml- 1 。出现不同程度的副作用 31例(37% )。结论　老年性癫痫的临床表现有别于青少年。对老年癫痫患者 ,应据其临床发作情况 ,有无药物不良反应 ,参考抗痫药浓度调整剂量。Objective: To investigate the serum concentration of antiepileptic drugs in the elderly patients with epilepsy. Methods: Seyum concentration was determined with the method of HPLC or TDX measurement.Results: Serum concentrations of phenytoin, carbamaze and pineor sodium valproate were respectively 12.1～51 μg·ml -1 ,3.54～15.1 μg·ml -1 ,28～127 μg·ml -1 in normal dose. Drug side effect appeared in 31 cases of various types of epilepsy who were treated with antiepileptic drugs. Conclusion: Dosage must beregulated, according to the clinical state and the appearance of drug side effect,and the levels of serum concentration of antiepileptic drugs.

关 键 词：癫痫 抗痫药 血药浓度 药物疗法 监测 诊断 治疗 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R971.6[医药卫生—临床医学]