肺癌支气管动脉化疗灌注前后癌胚抗原变化的临床研究  

作　　者：高峰[1] 谢春明[1] 杨敏玲[1] 冯对平[1] 庞宁东[1] 陈毅[1] 

机构地区：[1]山西医科大学第一附属医院放射科,030001

出　　处：《当代医学》2012年第14期7-8,共2页Contemporary Medicine

摘　　要：目的探讨肺癌行支气管动脉化疗灌注术前后癌胚抗原(Carcino-embryonic antigen,CEA)的变化,以讨论其治疗肺癌的临床疗效。方法 33例经病检证实为肺癌的患者,在术前监测CEA的值。33例患者均经股动脉插管,行支气管动脉化疗灌注术。灌注的化疗药物为:氟脲嘧啶0.5g+奥沙利铂50mg+丝裂霉素或阿霉素20mg。术后1月再次监测CEA的值,比较术前及术后一月的CEA值。结果所有患者均一次性插管成功,术前的CEA为1.37～38.38,平均为(14.45±9.62),术后1月的CEA为1.02～29.90,平均为(8.48±7.97),P<0.05,差别有统计学意义。结论肺癌行支气管动脉化疗灌注术后的CEA值明显低于术前,可见支气管动脉化疗灌注术治疗肺癌是一种有效的治疗方法。Objective To investigate the changes of CEA in lung cancer which received bronchial arterial chemotherapy infusion and to discuss the clinical efficacy of treatment of lung cancer.Methods The 33 cases diagnosed lung cancer by pathology were monitored CEA preoperatively,then they received bronchial arterial chemotherapy infusion.The chemotherapy drugs were fluorouracil 0.5g,oxaliplatin 50 mg and mitomycin or doxorubicin 20 mg.CEA was monitored 1 month later and compared with preoperative one.Results Success was achieved in all patients.The value of CEA in preoperative was（14.45 ± 9.62）,the value of CEA in postoperative was（8.48±7.97）,P0.05,the difference was statistically significance.Conclusion The value of CEA in preoperative is significantly lower than the value of CEA in postoperative,showing that bronchial arterial chemotherapy infusion is an effective treatment method for lung cancer.

关 键 词：肺癌 支气管动脉化疗灌注术 癌胚抗原 

分 类 号：R734.2[医药卫生—肿瘤]