泮托拉唑治疗消化性溃疡合并出血48例疗效观察  

作　　者：叶泽辉[1] 温晓雯[1] 

机构地区：[1]广东省东莞市人民医院,523000

出　　处：《当代医学》2012年第14期9-10,共2页Contemporary Medicine

摘　　要：目的观察泮托拉唑治疗消化性溃疡合并出血的疗效。方法将96例消化道溃疡出血患者随机分为两组,每组各48例泮托拉唑组给予泮托拉唑40mg加入100ml生理盐水,静脉滴注,每日2次。西咪替丁组给以西咪替丁400mg加入5%葡萄糖溶液250ml静脉滴注,每日2次。疗程结束后,对比两组疗效。结果泮托拉唑组显效25例,有效21例,显效率52.08%,总有效率95.83%;西咪替丁组显效13例,有效20例,显效率27.08%,总有效率68.75%。泮托拉唑组显效率与总有效率均显著高于西咪替丁组,显著性差异具有统计学意义(P<0.05)。结论泮托拉唑治疗消化道溃疡合并出血疗效优于西咪替丁,不良反应轻,值得临床推广应用。Objective To summarize the efficacy of pantoprazole in the treatment of peptic ulcer bleeding.Methods Ninty-six cases of peptic ulcer bleeding patients were randomly divided into two groups.Pantoprazole group were treated with pantoprazole 40 mg 100 ml normal saline,intravenous injection of two times a day.The cimetidine give cimetidine 400 mg add 5% glucose solution 250 ml intravenous infusion two times a day.After treatment,compared to after treatment.Results In pantoprazole group,25 cases were markedly effective,21 cases were effective,the effective rate was 52.08%,the total efficiency of 95.83%;in cimetidine group,13 cases were markedly effective and 20 cases were effective,the effective rate was 27.08%,the total efficiency of 68.75%.Pantoprazole group efficiency and the total effective rate was significantly higher than the cimetidine group,the differences all were significant（P0.05）.Conclusion Compared with cimetidine,it is effective with light hemorrhage reaction to pantoprazole in the treatment of peptic ulcer bleeding,it is suitable for clinical application.

关 键 词：消化性溃疡 出血 泮托拉唑 西咪替丁 

分 类 号：R573.1[医药卫生—消化系统]