柔脉胶囊降脂及抗氧化作用的研究  

STUDY ON HYPOLIPEMIC AND ANTI-OXIDATIVE EFFECT OF ROU MAI CAPSULE

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作  者:顾耀林[1] 黄爱平[2] 梁军[1] 喻如明 郝富强[1] 欧三桃[1] 

机构地区:[1]泸州医学院附属医院老干病房 [2]泸州医学院药理学教研室,646000 [3]泸州郎酒集团公司职工医院

出  处:《泸州医学院学报》2000年第1期29-31,共3页Journal of Luzhou Medical College

基  金:四川省教委重点科研资助

摘  要:目的 :探讨柔脉胶囊调整血脂及抗氧化的作用。方法 :选择血脂异常患者 1 1 9例 ,治疗组 (柔脉胶囊组 ) 78例 ,对照组 (地奥心血康 ) 4 1例 ,全部连续服药 1 2周 ,观察血脂及过氧化脂质 (LPO)的变化。结果 :治疗组总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C)和TC/高密度脂蛋白胆固醇 (HDL C)在用药后第 8、1 2周比用药前显著降低。甘油三脂 (TG)、HDL C在用药后 4、8、1 2周较用药前亦有显著下降 ,柔脉胶囊对TC、TG、HDL -C和TC/HDL C的总有效率分别为 72 .34 %、92 .5 2 %、80 .6 4%和 74.43% ,与对照组比较有显著性差异 (P <0 .0 1 )。用药前、后血清LPO比较有显著下降 (P <0 .0 1 )。结论 :柔脉胶囊有良好的调整血脂异常和抗氧化作用。Objective: To inquire into the role of Rou Mai Capsule in regulating serum lipid and Anti oxidation. Methods: 119 cases of hyperlipemic patients were randomly divided into two groups: 78 cases treated with Rou Mai Capsule as the test group and 41 cases with medication of Di Ao Xin Xue Kang as the control group. The drugs were administered to all the patients for 12 weeks, and serum lipid were observed before and after 4, 8 and 12 weeks, treatment and serum LPO was then examined before and after medication respectively. Results: In the test group, TC, LDL C and TC/HDL C apparently dropped at the 8th and 12th week (P<0.01). However, there was no siginficant difference at the 4th week (P>0.05). The experiment also showed that it has the effect of lowering TG and raising HDL C at 4th, 8th and 12th week(P<0.05,P<0.01). In the control group, TC were dropped after 12 weeks treatment(P<0.05), and HDL C were elevated at the 4th, 8th and 12th week(P<0.01), others had no significant difference(P>0.05). The total effective rates of Rou Mai Jiao Lang on TC,TG, HDL C and TC/HDL C were 72.34%, 92.5%, 80.64% and 74.43% respectively. Serum LPO were dropped after 12 weeks, treatment in the two groups(P<0.01). Conclusion: The results suggested that Rou Mai Jiao Lang has serum Lipid regulation and anti oxidation effects.

关 键 词:柔脉胶囊 降血脂 中成药 抗氧化作用 

分 类 号:R286.26[医药卫生—中药学]

 

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