12例头颈部髓外浆细胞瘤的病理与免疫组化研究  

Extramedullary plasmacytoma of the head and neck:A clinicopathologic,immunohistochemistry study

作　　者：周光耀[1] 高炳庆[1] 刘亚峰[1] 张贤良[2] 王建琼[3] 

机构地区：[1]华西医科大学附属第一医院耳鼻咽喉科,成都610041 [2]华西医科大学附属第一医院病理科 [3]华西医科大学公共卫生学院卫生统计学教研室

出　　处：《临床耳鼻咽喉科杂志》2000年第4期168-170,共3页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨头颈部髓外浆细胞瘤 ( EMP)的组织学特点、临床行为、免疫球蛋白分泌功能与预后的关系。方法 :对 12例头颈部 EMP患者的手术蜡块进行病理观察与免疫组化检测。结果 :12例中 ,低度恶性 ( 级 ) 3例 ,中度恶性 ( 级 ) 3例 ,高度恶性 ( 级 ) 6例 ;免疫组化显示肿瘤均为单克隆性 ,Ig Gκ、Ig Gλ阳性各 6例。除鼻咽部 2例外 ,均接受手术切除加放疗。 、 、 级 EMP 5年生存率分别为 75 .0 %、6 2 .0 %、37.6 % ;Ig Gκ阳性者6 8.5 % ,Ig Gλ阳性者 37.5 % ,两者有显著性差异 ( P <0 .0 1)。结论 :免疫组化检测对头颈部 EMP鉴别诊断有重要作用 ,手术加放疗为有效的治疗手段 ,组织学分级。Objective:To investigate the relation between histopathological feature,clinical behavior characters,immunoglobulin (Ig) secretory function and prognosis of the extramedullary plasmacytoma (EMP) of the head and neck.Method:12 cases of EMP in the head and neck region were studied retrospectively.The clinicopathological records from January,1977 to December,1996 were reviewed.Immunohistochemical (IHC) stains for detecting intracytoplasmic immunoglobulin kappa (IgGκ) and lambda (IgGλ) were carried out.Result:10 cases of the patients were male and 2 female;Their ages ranged from 32 to 67 years with an average of 57 years.The tumors were located in the nasosinus(6),nasopharynx(2)、Larynx(3) and ear(1).Low (Ⅰ)、intermediate (Ⅱ) and high grade (Ⅲ) tumors were 3,3 and 6 cases respectively.Two patients with EMP of nasopharynx were treated with radiotherapy,in others radiotherapy was administered after complet surgical resection.Follow up time ranged from 10 to 76 months.IHC showed monoclonality of the plasma cell and was positive for IgGλ (6 cases) and IgGκ (6 cases,conferming the identical clonal origin of the plasma cells.The 5 year survival for grade Ⅰ、Ⅱ and Ⅲ were 75.0 %, 62.0 % and 37.6 %, 37.5 % and 68.50 % for IgGλ positive and IgGκ positive cases,respectively.There are statistically significance between them (P< 0.01 ).Conclusion:EMP in head and neck region are rare plasma cell tumors.IHC play an important role in differential diagnosis.The combination of surgery and radiotherapy proved to be an adequate and effective treatment.The grading and IgG secretory function may be valuable for predicting the prognosis of EMP.

关 键 词：髓外浆细胞瘤 头颈部肿瘤 免疫组织化学 病理 

分 类 号：R739.910.2[医药卫生—肿瘤]