北京市中老年人群甘油三酯水平与颈动脉新发斑块关系的研究  

Association between both triglyceride level, newly identified carotid plaque and middle-aged andelderly population, Beijing

作　　者：张晓婷[1,2,3] 赵冬[1] 刘静[1] 冯立群[1] 孙佳艺[1] 王淼[1] 刘军[1] 王薇[1] 

机构地区：[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病学研究室,100029 [2]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所,神经内科,100029 [3]延边大学医学部内科系

出　　处：《中华流行病学杂志》2012年第5期455-459,共5页Chinese Journal of Epidemiology

基　　金：“十一五”国家科技支撑计划（2006BAl01A02）;国家自然科学基金（81170266,81070226,81000109）

摘　　要：目的探讨甘油三酯（TG）水平与北京市中老年人群5年颈动脉新发斑块的关系，分析TG合并心血管疾病传统危险因素对颈动脉新发斑块的预测作用。方法应用队列研究方法，选取北京市两社区人群TG指标和基线复查两次颈动脉超声检测数据完整者共1949人作为研究对象。将基线TG分为4组：组1（〈1．13mmol／L）、组2（1．13-1．69mmol／L）、组3（1．70-2．25mmol／L）及组4（≥2．26mmol／L），以颈动脉新发斑块作为动脉粥样硬化进展的评价指标，分析基线TG水平与颈动脉新发斑块的关系。结果不同TG水平组间新发斑块率比较，新发斑块率随着基线TG水平的上升而增加（分别为30．8％、38．8％、41．9％和44．2％，X^2=21．22，P〈0．01）。单因素分析显示：与组1相比，TG≥1．13mmol／L可增加颈动脉新发斑块风险（组2、3、4分别增加了42％、62％和78％）；调整年龄、性别及传统危险因素后，TG水平在2．26mmol／L以上人群，颈动脉新发斑块风险增加37％。结论北京市中老年人群颈动脉新发斑块率随着基线TG水平的上升而增加。高TG（≥2．26mmol／L）可增加中老年人群颈动脉新发斑块的危险。Objective To evaluate the association between triglyceride（TG） level and newly identified 5-year carotid plaque and to explore the prediction value of TG level on the newlyidentified carotid plaque with risk factors of traditional atherosclerosis. Methods A cohort study was adopted. The baseline survey including CVD risk factors and B-mode ultrasound of carotid artery was performed in 2002, and the second follow-up examination was performed in 2007. We evaluated 1949 participants with lipid measurements and B-mode ultrasound of carotid arteries in the two surveys （with mean age as 57.9 ± 8.1 years and 39.2% were men）. The baseline TG levels were divided into four groups： group 1 （TG〈I.13 retool/L） , group 2 （TG=1.13-1.69 mmol/L） , group 3 （TG= 1.70-2.25 retool/L） and group 4 （TG≥2.26 mmol/L）. Newly identified carotid plaque was regarded as the indicator of progression of carotid atherosclerosis. New relationship between fasting TG levels and newly identified carotid plaque was analysed. Results Compared to newly identified carotid plaque which including different TG level groups, the incidence of newly artery plaque had significantly increased along with the increase of baseline triglyceride level （30.8%, 38.8%, 41.9% and 44.2% respectively, with Z2=21.22 ,P〈0.01 ）. Compared to individuals （TG〈 1.13 mmol/L） ,TG seemed a risk factor of plaque progression （P〈0.01）. After adjusted for age, sex, dyslipidemia and other risk factors, high TG group （TG≥2.26 mmol/L） appeared a significant independent predictor ofnewly identified carotid plaque （OR=1.37, 95% CI： 1.00-1.86）. When further stratifying the traditional atherosclerosis risk factors, we found that high TG group with smoking or hypertension was an independent factor of atherosclerosis progression. Conclusion With the increase of triglyceride levels, the rate of newly identified carotid plaque also increased. After adjusting age, sex, dyslipidemia and other risk factors, serum fasting TG ≥2.26 mmol/L a

关 键 词：甘油三酯 颈动脉斑块 血脂异常 动脉粥样硬化 

分 类 号：R743.3[医药卫生—神经病学与精神病学]