细胞间黏附因子-1与呼吸系统疾病  

Research progress of intercellular adhesion molecules-I in respiratory disease

作　　者：焦晓丹[1] 袁雅冬[1] 

机构地区：[1]河北医科大学第二医院呼吸内科,石家庄050000

出　　处：《国际呼吸杂志》2012年第8期618-623,共6页International Journal of Respiration

摘　　要：细胞间黏附因子-1是免疫球蛋白超家族成员之一，介导炎症细胞的黏附、渗出，并选择性募集于病理损伤组织，促进细胞因子及炎性物质的释放，在急性肺损伤及肺缺血灌注损伤中发挥重要作用。近年来越来越多的研究发现，细胞间黏附因子-1与慢性阻塞性肺疾病、肺癌的转移、支气管哮喘及肺纤维化等亦密切相关，参与多种肺部疾病的发生、发展。Intercellular adhesion molecules-1 （ICAM-1） is a member of immunoglobulin superfamily, which mediates leucocytes adhesion and rolling, and recruites leukocytes to the inflamed tissue, and promotes the release of the inflammatory mediators, and it plays an important role in acute lung injury and lung ischemia reperfusion injury. Recent researches have estimated that ICAM-1 is also involved in the pathogenesis of chronic obstructive pulmonary disease, metastasis of lung cancer, bronchial asthma, pulmonary fibrosis and other dieases. ICAM-1 is correlated with respiratory system diseases.

关 键 词：细胞间黏附因子-1 巨细胞分化抗原-1 呼吸系统疾病 

分 类 号：R363[医药卫生—病理学]