Caveolin-1在食管鳞癌中的表达及其临床意义  

Expression and clinical significance of Caveolin-1 in esophageal squamous cell carcinoma

作　　者：葛腾飞[1] 朱克超[1] 于在诚[1] 汪渊[2] 

机构地区：[1]安徽医科大学第一附属医院胸外科,合肥230022 [2]安徽医科大学分子生物学实验室,省部共建重要遗传病基因资源利用重点实验室,合肥230032

出　　处：《安徽医科大学学报》2012年第5期544-547,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:30471427);安徽省科技厅重点科研项目(编号:07021017)

摘　　要：目的探讨Caveolin-1蛋白在食管鳞癌中的表达及其临床意义。方法应用免疫组化法和免疫印迹法检测65例食管鳞癌患者的癌组织及对应癌旁正常食管黏膜中Cave-olin-1的表达情况。结果食管鳞癌组织中Caveolin-1蛋白的表达水平高于对应癌旁正常食管黏膜,差异有统计学意义(P<0.05),食管鳞癌组织中Caveolin-1蛋白的表达水平与其分化程度相关(P<0.05),与淋巴结转移、TNM分期等无关。结论 Caveolin-1蛋白在食管鳞癌中的高表达可能与其发生发展有关。Objective To investigate the expression and clinic characteristics of Caveolin-1 in esophageal squamous cell carcinoma（ESCC）.Methods Expression of Caveolin-1 in 65 patients of ESCC and normal esophageal epithelial tissue were detected by immunohistochemistry and Western blot analysis.Results The expression level of Caveolin-1 was significantly higher in ESCC than that in the normal esophageal epithelial tissue（P〈0.01）,and up-regulation of Caveolin-1 was correlated with differentiation of ESCC.It had no relationship with lymph node metastasis or TNM stage.Conclusion The overexpression of Caveolin-1 may play an important role in the progression of human ESCC.

关 键 词：食管肿瘤 鳞状细胞 免疫组织化学 免疫印迹法 CAVEOLIN-1 

分 类 号：R735.1[医药卫生—肿瘤] R341[医药卫生—临床医学]