富血小板纤维蛋白修复牙种植体周围骨缺损的研究  

Study on restoration of bone defects around dental implants by platelet-rich fibrin

作　　者：杨全全[1] 何家才[1] 杨瑞[1] 陈镇[1] 方冬冬[2] 

机构地区：[1]安徽医科大学附属口腔医院颌面外科,合肥230032 [2]安徽医科大学第二附属医院口腔科,合肥230601

出　　处：《安徽医科大学学报》2012年第5期581-584,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽高校省级自然科学研究重点项目(编号:KJ2009A056Z);安徽省自然科学基金项目(编号:11040606M173);安徽医科大学博士科研资助基金(编号:XJ201034)

摘　　要：采用牙种植术将36颗牙种植体植于6只杂种犬双侧下颌缺牙区,同时在种植体近中造3.5 mm×3.5 mm×3.5mm的骨缺损,然后填入β-TCP/PRF混合物、β-TCP,另设空白对照组(不做任何处理)于各骨缺损区,分别于种植术后4、8、12周各处死2只犬,行大体、X线及组织学观察各个时期各组骨缺损区的成骨情况。植入的36颗种植体无脱落,无明显不良并发症发生。β-TCP/PRF混合物是一种良好的骨修复材料,具有促进新骨形成的作用,有利于骨组织的愈合。36 dental implants were separately implanted in each side of the mandibule of 6 dogs.At the same time,a 3.5 mm×3.5 mm×3.5 mm size bone defect was created in the mesial aspect of each implant.3 kinds of substitutes were grafted in the bone defects：β-TCP/PRF compounds,β-TCP and blank control（do not make any deal）.Every 2 dogs were sacrificed at 4,8 and 12 weeks after the implantation,and gross observation,X-rays and histopathology were examined.The results showed 36 dental implants did not fall off,and no severe complications occurred.So β-TCP/PRF is a better bone repair material with the promotion of new bone formation and the elevation of healing quality.

关 键 词：富血小板纤维蛋白 β相磷酸三钙 种植牙 骨缺损 

分 类 号：R782.05[医药卫生—口腔医学]