阿尔茨海默病患者脑表现扩散系数和各向异性分数图与简易智能状态检查评分的基于体素分析  

A voxel-based correlation analysis between mini-mental state examination scores and brain apparentdiffusion coefficients or fractional anisotropy image

作　　者：龙淼森[1] 倪红艳[1] 任津瑶[1] 龚必焱[1] 沈文[1] 祁吉[1] 

机构地区：[1]天津市第一中心医院放射科,天津300192

出　　处：《中华老年医学杂志》2012年第5期359-362,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金面上项目（30870713）;天津市卫生局科技基金面上项目（09KYl0）;天津市卫生局科技攻关基金（11KGl08）

摘　　要：目的采用基于体素的分析方法（VBA）前瞻性研究阿尔茨海默病（AD）患者扩散张量成像（DTI）表观扩散系数（ADc）和各向异性分数（FA）在体素水平上与简易智能状态检查（MMSE）评分的相关性。方法12例AD患者，平均年龄（70．04-10．5）岁和16例正常志愿者，平均年龄（66．5±6．7）岁，采用平面回波扩散序列和32通道线圈采集扩散张量数据获得ADC和FA图像。VBA观察AD患者ADC、FA值改变与神经心理学相关性。结果AD患者双侧颞叶、双侧前扣带束ADC值增高，FA值减低，左侧颞叶、左侧前扣带束ADC值增高和FA值减低范围大于右侧；AD患者双侧后扣带回ADC值增加，FA值无阈上差别；ADC值增高范围大于FA值减低范围。AD患者MMSE评分与右侧海马ADC值呈负相关（r=-0．9474，P=0．0232），与右侧海马FA值呈正相关趋势（r=0．5414，P-0．5853）。结论AD患者右侧颞叶病变程度和范围小于左侧，扩散张量成像ADC值优于FA值，与AD患者智能异常具有更密切的关系。Objective To investigate the voxel-based correlation of mini-mental state examination（MMSE） score with apparent diffusion coefficients（ADC） and fractional anisotropy （FA） derived from diffusion tensor imaging（DTI） in the patients with Alzheimer disease. Methods 12 patients aged （70.0±10.5） years and 16 normal control aged （66.5±6.7） years were enrolled in this study. DTI was performed based on sequence and 32-channei head coils. ADC and FA images were calculated and normalized to the same space and smoothed with 8 mm Gaussian Kernel. With statistical parameter mapping software SPM5 package, the independent two sample t-test with general linear model were performed to detect ADC and FA differences between AD patients and normal control. Correlation analysis was performed between MMSE score and FA or ADC. Results AD patients showed elevated ADC value and decreased FA value in bilateral temporal lobe and anterior cingulate, which was more pronounced in the left than in the right. There was elevation of ADC value but no FA decrease in bilateral posterior cingulate. The abnormal ADC area was larger than that of FA. There was negative correlation between MMSE score and ADC of the right hippocampus（r=0. 9474,P=0. 0232） and a tendency towards positive correlation between MMSE score and FA of the right hippocampus（ r= 0. 5414, P=0. 5853）. Conclusions ADC value may be more sensitive than FA value in DTI. Right temporal lobe microstructure involvement is less severe, but has a stronger relationship with neuroosvchological abnormality.

关 键 词：阿尔茨海默病 磁共振成像 认知障碍 

分 类 号：R749.16[医药卫生—神经病学与精神病学]