32例儿童发作性睡病临床特征分析  

Clinical features of Chinese children with narcolepsy： a report of 32 cases

作　　者：鞠俊[1] 赵建波 李晓燕[1] 石秀玉[1] 张玮娜[1] 邹丽萍[1] 

机构地区：[1]解放军总医院儿童医学中心,北京100853 [2]儿童医院神经与康复中心,北京市100045

出　　处：《中华神经医学杂志》2012年第5期493-496,共4页Chinese Journal of Neuromedicine

摘　　要：目的加强对儿童发作性睡病临床特征及诊断方法的认识。方法回顾性分析自2008年9月至2011年9月北京市儿童医院神经科和解放军总医院儿童医学中心收治的32例发作性睡病患儿资料，同时对相关文献进行回顾分析。结果32例发作性睡病患儿均有日间不可抗拒的入睡发作，26例（8l.3％）存在猝倒发作，11例（34．4％）存在睡眠幻觉，仅2例（6．25％）存在睡眠瘫痪表现。患儿多以日间睡眠增多为起病症状，大多数患儿有夜间睡眠紊乱、易激惹的临床表现，性格改变、食欲及体重增加、青春期提前也是常见的临床症状。多次小睡睡眠潜伏期试验（MSLT）检查在患儿中阳性率较低，可能与患儿年龄小、病程短等因素有关。结论不可抗拒的入睡发作、猝倒发作是中国儿童发作性睡病典型的临床表现，结合多导睡眠图和MSLT可明确诊断。Objective To raise the awareness of childhood narcolepsy. Methods We analyzed the clinical data of 32 children with narcolepsy and review the literature. Results All the patients manifested as excessive daytime sleepiness with irresistible sleep attacks. Cataplexy appeared in 26 cases （81.3%）, hypnagogic hallucination in 11 cases （34.4%）, and sleep paralysis in merely 2 cases （6.25%）. Daytime sleepiness was the first symptom in most cases. Common features included night sleep disorder, emotional disorder, excessive weight gain, and earlier puberty. Owing to the young age and short duration, a few children could have the false negative multiple sleep latency test （MSLT） results. Conclusion Excessive daytime sleepiness with irresistible sleep attacks and cataplexy are the typical clinical manifestations of Chinese narcoleptic children. A definite diagnosis is established on the comprehensive analysis of symptoms and assistant examination.

关 键 词：发作性睡病 多导睡眠图 多次小睡睡眠潜伏期试验 

分 类 号：R740[医药卫生—神经病学与精神病学]