参一胶囊联合放疗对晚期非小细胞肺癌疗效的临床观察  

Therapeutic effects of gensenoside-Rg3 combined with radiotherapy on advanced non-small cell lung cancer

作　　者：姜新[1] 辛颖[2] 罗景华[1] 常鹏宇[1] 冯奇[3] 曲雅勤[1] 

机构地区：[1]吉林大学第一医院肿瘤中心放疗科,长春130021 [2]吉林大学病理生物学教育部重点实验室 [3]吉林大学第二医院放疗科

出　　处：《中华放射医学与防护杂志》2012年第2期196-198,共3页Chinese Journal of Radiological Medicine and Protection

基　　金：基金项目：吉林省科技厅基金（200705221）;吉林省发展与改革委员会基金（2010019-1）

摘　　要：目的 应用参一胶囊联合放疗治疗Ⅲ、Ⅳ 期非小细胞肺癌（NSCLC）,观察其临床疗效及不良反应。方法 63例Ⅲ、Ⅳ期NSCLC患者按简单随机化方法分为2组,治疗组,35例,给予放疗＋参一胶囊处理;对照组,28例,放疗＋安慰剂处理。比较2组患者的疗效及不良反应。结果 治疗组的近期疗效为57.14%, 显著高于对照组（32.14%,χ2=3.91,P〈0.05）,治疗组的中位生存期为14.2个月,显著长于对照组（11.2个月, χ2=2.07,P〈0.05）,治疗组的1年生存率为62.86%,显著高于对照组（39.29%, χ2=4.40,P〈0.05）;治疗组中各种常见的不良反应（除咳嗽、发热外）发生率,均低于对照组,但两组间差异无统计学意义。结论 参一胶囊联合放疗是治疗晚期NSCLC的有效方法,具有一定的减毒增效作用。Objective To study the efficacy and toxicity of gensenoside-Rg3 （Rg3） combined with radiotherapy on non-small cell lung cancer （NSCLC） at advanced stages （Ⅲ and Ⅳ）. Methods Sixty-three patients with stage Ⅲ or ⅣNSCLC were divided randomly into two groups： treatment group （n=35） treated with Rg3 combined with radiotherapy and control group （n=28） treated with radiotherapy alone.The efficacy and side effects were compared after the treatment. Results The response rate （CR＋PR） of the treatment group was 57.14%, significantly higher than that of the control group （32.14%, χ2=3.91, P〈0.05）. The median survival time of the treatment group was 14.2 months, significantly longer than that of the control group （11.2 months, χ2=2.07,P〈0.05）. The one-year survival rate of the treatment group was 62.86%, significantly higher than that of the control group （39.29%, χ2=4.40,P〈0.05）. The incidence rates of side effects of the treatment group were all lower than those of the control group, but there were not significant difference. Conclusions Gensenoside-Rg3 combined with radiotherapy is effective for advanced stage NSCLC, with attenuation and synergistic effects.

关 键 词：参一胶囊 放疗 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]