α-氟-β-氨基酸酯的合成  

Synthesis of α-Fluoro-β-amino Esters

作　　者：张鹏[1,2] 王超[1] 周莉[1] 孙健[1] 

机构地区：[1]中国科学院成都生物研究所天然产物研究中心,四川成都610041 [2]中国科学院研究生院,北京100049

出　　处：《合成化学》2012年第3期389-392,共4页Chinese Journal of Synthetic Chemistry

摘　　要：采用简易方法从取代苯乙酮出发制得α-氟-β-脱氢氨基酸酯;在N,N-二甲基甲酰胺存在下用三氯硅烷将其还原,高收率和非对映选择性地合成了α-氟-β-氨基酸酯,其结构经1H NMR,13C NMR和MS确证。α-Fluoro-β-amino esters in high yield with diastereoselectivity were synthesized using tri- chlorosilane as a reducer in the presence of DMF by a reduction of α-Fluoro-β-enamino esters which were prepared from aeetophenones by a simple method. The structures were confirmed by 1 H NMR, 13C NMR and MS.

关 键 词：α-氟-β-氨基酸酯 三氯氢硅 非对映选择性 还原反应 合成 

分 类 号：O629.1[理学—有机化学]