颅内静脉窦血栓形成22例临床分析  

Clinical analysis on 22 patients with cerebral venous sinus thrombosis

作　　者：王利群[1] 周翠玲[1] 张延霞[1] 

机构地区：[1]88医院

出　　处：《实用医药杂志》2012年第5期391-393,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨颅内静脉窦血栓形成的临床特点。方法回顾性分析22例确诊的颅内静脉窦血栓形成患者的临床资料。结果 6例误诊(27.27%)。22～44岁、45～59岁及60岁以上病死率分别为7.14%、66.67%及80.00%,而显示年龄越大病死率越高,且误诊组病死率显著高于非误诊组(66.60%vs 18.75%,χ2=4.441,P=0.035<0.05)。头痛为首发及主要症状,非炎症病因为主,孕产妇多见。早期脑CT及脑MRI平扫可发现位于皮层脑叶的多发性病灶及静脉阻塞性脑肿胀。结论颅内静脉窦血栓形成临床表现复杂多样,易误诊,且年龄较大病死率可能越高。抗凝治疗是安全有效的。Objective To explore the clinical characteristic and treatment of cerebral venous sinus thrombosis（CVST）.Methods A retrospective study on the clinical data of cerebral vein and sinus thrombosis in 22 patients was conducted.Results Six patients were misdiagnosed primarily,accounted 27.27% of the 22 patients.Of 22 cases,7 were of complete recovery,8 were improved,7 died,and the deterioration and fatality rate was 31.82%.In this study,the older the patients were,the higher ratio of death was（χ2=11.494,P=0.0030.05）.Additionally,there was higher ratio of death in the misdiagnosed group than the diagnosed group（χ^2=4.441,P=0.0350.05）.Cerebral venous sinus thrombosis was mostly induced by non-inflammatory diseases,and headache was frequently the initial cardinal symptom.Magnetic resonance imaging of the venous sinuses and digital subtraction angiography could early find the multi-lesion at cerebral lobe and vein-thrombosis cerebral swelling.Conclusion Cerebral venous sinus thrombosis is a rare and special ischemic cerebrovascular disease with complicated clinical presentations and high mortality,which was easily misdiagnosed.Anticoagulant therapy is safe and effective for this disorder.

关 键 词：静脉窦 血栓形成 抗凝治疗 

分 类 号：R743.32[医药卫生—神经病学与精神病学]