性激素结合蛋白基因多态性与肝细胞癌患者术后复发关系研究  

Association between SHBG-SNP Asp327Asn and recurrence of primary hepatocellular carcinoma after radical resection

作　　者：刘顺[1] 曾小云[1] 柏桦[1] 许杨[1] 张艳艳[1] 潘冬香[1] 毛良勤[1] 黄秋兰[1] 仇小强[2] 

机构地区：[1]广西医科大学公共卫生学院流行病学教研室,南宁530021 [2]桂林医学院公共卫生学院,广西541004

出　　处：《中国临床新医学》2012年第5期381-384,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西科学研究与技术开发资助项目(编号:桂科攻0993003D-4);广西研究生教育创新计划资助项目(编号:2011105981004M171)

摘　　要：目的探讨性激素结合蛋白(SHBG)基因Asp327Ash位点单核苷酸多态性与肝细胞癌(Hepa-tocellular Carcinoma,HCC)根治术后早期复发的关系。方法收集131例实施根治性切除术的原发性HCC患者临床病理、血液DNA及预后生存资料,以单因素分析、多因素Cox风险回归分析临床病理及Asp327Asn位点多态性与HCC术后复发关系,用Kaplan-Meier生存曲线描述各基因型的无复发生存时间,并对不同基因型无复发生存曲线进行Log-Rank检验比较。结果全组病例1、2年生存率分别为87%、76%,累积复发率分别为17%、19%。单因素及多因素分析均显示结节数可能与术后复发有关,而Asp327Asn位点多态性可能与术后复发无关。生存分析显示,在单一结节数的HCC患者中,虽然Asp/Asn+Asn/Asn、Asp/Asp基因型无复发生存时间比较差异无统计学意义(P=0.21),但生存曲线后半段明显分离。结论 SHBG基因Asp327Asn位点多态性可能与HCC术后复发无关,但是对于肝脏基本状况较好的HCC患者,该位点多态性可能对其术后远期预后有一定的影响。Objective To investigate the association between SHBG-SNP Asp327Asn and recurrence of hep- atocellular carcinoma （HCC） after radical resection. Methods Materials of clinical pathology, blood DNA and prog- nosis survival of 131 HCC patients were collected. Univariate analysis and multivariate Cox regression analysis were used to detect the factors of recurrence of primary HCC after radical resection. The recurrence-free survival curves of genotypes of Asp327Asn were described by Kaplan-Meier analysis and the survival times were compared by Log-Rank test. Results The overall survival rate and cumulative recurrence rate for 1, 2 years were 87%, 76% and 17%, 19% respectively. Both univariate analysis and multivariate analysis showed only number of nodules but not the poly- morphism of Asp327Asn was related to the recurrence of HCC after radical resection. Survival analysis showed that, among HCC patients with a single nodule, although the recurrence-free survival time of Asp/Ash ＋ Asn/Asn and Asp/Asp genotypes had no statistical difference （ P = 0. 21 ） , the later part of the survival curves separated obviously. Conclusion Polymorphism of SHBG-SNP Asp327Asn may be not associated with recurrence of HCC after radical resection. However, polymorphism of the locus may have a certain influence on the long-term prognosis to those with a good liver basic condition.

关 键 词：肝细胞癌 性激素结合蛋白 单核苷酸多态性 生存分析 

分 类 号：R735.7[医药卫生—肿瘤]