MAGE-A3在鼻咽癌中的表达及临床意义  

Expression of MAGE-A3 antigen in nasopharyngeal cancer and its clinical significance

作　　者：周安秀[1] 廖红[1] 李小琳[1] 杨静[1] 左懿[1] 饶源[1] 王洁[1] 陶凝[1] 韦维[1] 雷茵[1] 

机构地区：[1]广西医科大学组织胚胎学教研室,南宁530021

出　　处：《中国临床新医学》2012年第5期397-401,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西科学基金资助项目(编号:桂科基0575059)

摘　　要：目的检测癌-睾丸抗原(cancer-testis antigen,CTA)黑色素瘤抗原-A3(Melanoma antigen A3,MAGE-A3)蛋白在鼻咽癌(nasopharyngeal cancer,NPC)组织中的表达,为NPC诊断标记物及其肿瘤免疫治疗的可行性提供理论基础。方法用免疫组织化学法检测病理确诊的51例NPC组织和20例鼻咽部黏膜慢性炎症组织中MAGE-A3的表达情况,并将其表达结果与临床指标进行统计学分析。结果 MAGE-A3在NPC组织中的阳性表达率为64.71%(33/51);在鼻咽部黏膜慢性炎症组织中几乎不表达,只有2例呈弱阳性,两者之间差异有统计学意义(P<0.01);MAGE-A3表达与NPC患者的性别、年龄、疾病临床分期、有无淋巴结转移无明显相关性(P>0.05)。结论 MAGE-A3在NPC组织中呈较高表达,提示MAGE-A3有作为靶抗原的可能用于NPC免疫诊断和治疗。Objective To detect the expression of cancer testis antigen （CTA） MAGE-A3 protein in human nasopharyngeal cancer（NPC） patients as well as rhinitis patients and explore its feasibility in developing special vaccine, immunodiagnosis, and immtmotherapy of NPC. Methods Immunohistoehemistry method was used to detect the expression of MAGE-A3 antigen in tissues of 51 NPC patients as well as 20 rhinitis patients. The results of expression and clinical parameters were analyzed with SPSS software. Results The Expression of MAGE-A3 was observed in 33 out of 51 NPC patients and 2 out of 20 rhinitis patients; the differences was statically significant （P 〈 0.01 ）. The expression of MAGE-A3 in NPC was not correlated with gender, age, lymph node metastasis status, or TNM stages （P 〉 0. 05 ）. Conclusion MAGE-A3 antigen is expressed in NPC at a high frequency,which suggests that MAGE-A3 may be used as target antigen for immunodiagnosis and immunotherapy of NPC.

关 键 词：黑色素瘤抗原-A3 鼻咽癌 免疫组织化学法 

分 类 号：R739.72[医药卫生—肿瘤]