LEF-1的调控及其与肿瘤的关系研究进展  

Advances of the study on the regulation of Wnt/LEF-1 signal pathway and the relation with tumor

作　　者：崔婷婷[1] 谢楠[1] 张小莉[1] 吴琴丰[1] 聂红娟[1] 杨敏敏[1] 陈亦雯[1] 侯颖春[1] 

机构地区：[1]陕西师范大学生命科学学院,陕西710062

出　　处：《生命科学》2012年第5期439-443,共5页Chinese Bulletin of Life Sciences

基　　金：陕西师范大学创新实验基金;勤助科研创新基金

摘　　要：淋巴细胞增强因子(lymphoid enhancer factor,LEF-1)是Wnt信号通路中的一个重要调控因子。其异常表达对肿瘤细胞增殖和凋亡调控起关键作用。LEF-1作为Wnt信号通路核内的转录因子,还与T细胞受体α(TCRα)的增强子相互作用形成特定的构象,从而与其他因子结合共同调节基因的表达。同时,LEF-1为一多启动子基因,编码产生致瘤的全长形式的LEF-1和对Wnt信号通路起负向调控作用的截短形式的LEF-1。诸多研究结果表明肿瘤的发生发展与LEF/TCF各亚型的比例有关。就Wnt/LEF-1信号通路的调控以及与肿瘤的关系做一综述。LEF-1 is an important regulator in Wnt signaling pathway, its abnormal expression plays a key role in the cell proliferation and apoptosis, especially for the tumor cells. As a key regulator of Wnt signaling pathway, the specific conformation assembled by LEF-1 and T cell receptor α （TCRα） enhancer regulates gene expression with other factors together. Additionally, LEF-l is a multi-promoter driving gene and encodes a full-length form of the LEF-1 involving in oncogenesis and a truncated form of the LEF-1 regulating Wnt signaling pathway negatively. Reported data shows that the oncogenesis and tumor development are closely associated with the expression level change of LEF / TCF subtypes. We review the recent advances about LEF-1 as a regulator in Wnt pathway and its relationship with oncogenesis and progression of tumors in this paper.

关 键 词：LEF-1 WNT信号通路 调控 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]