万拉法新与阿米替林治疗抑郁发作疗效比较  

Effeet comparision of Venlafaxine and Amitriptyline in the treatment of depression

作　　者：孟宪军[1] 

机构地区：[1]赤峰学院第二附属医院,内蒙古赤峰024000

出　　处：《吉林医学》2012年第14期2941-2942,共2页Jilin Medical Journal

摘　　要：目的:比较万拉法新与阿米替林治疗抑郁发作的疗效及不良反应。方法:选择符合CCMD-3诊断标准的抑郁发作64例,随机分为万拉法新组(33例)和阿米替林组(31例),疗程为6周。用汉密尔顿抑郁量表(HAMD)和药物不良反应量表(TESS)评定疗效和药物的不良反应。结果:万拉法新组起效时间明显早于阿米替林组,且不良反应少而轻,但总的疗效二者相当。结论:万拉法新治疗抑郁发作疗效好、起效时间快、不良反应轻,患者服药依从性好。Objective To investigate the efficacy and adverse effects of Venlafaxine and Amitriptyline in the treatment of depression.Method Total 64 patients with depression were randomly divided into Venlafaxine group and Amitripty-line group for a double-blind investigation.The total treatment time was 6 weeks.Hamiltom Depression Scale（HAMD） was used for evaluating the therapeutic effect,while Treatment Emergent Symptom Scale（TESS） for side effects.Results HAMD scores of Venlafaxine group was more reducing than Amitriptyline group at the second and fourth weekend,and had significant difference between the two groups.The first took effects were more quickly than the last,but the final therapeutic efficacy of Venlafaxine was similar to that of Amitriptyline.The adverse effects of Venlafaxine were less and lighter.Conclusion Venlafaxine is effective and safe in the treatment of depression.And the effective time is short.It suggests that Venlafaxine might be one of the first-line anti-depressants.

关 键 词：万拉法新 阿米替林 抑郁发作 

分 类 号：R749.4[医药卫生—神经病学与精神病学]