PTEN mRNA和Smad4 mRNA在甲状腺乳头状癌中的表达及意义  

EXPRESSION AND CLINICAL SIGNIFICANCE OF PTEN MRNA AND SMAD4 MRNA IN PAPILLARY THYROID CARCINOMA

作　　者：黄亮[1] 刘镭[2] 黄旭[1] 李青山[1] 徐大为[2] 

机构地区：[1]承德医学院附属医院,河北承德067000 [2]承德医学院

出　　处：《承德医学院学报》2012年第2期126-128,共3页Journal of Chengde Medical University

摘　　要：目的:探讨PTEN mRNA、Smad4 mRNA在甲状腺乳头状癌(PTC)中的表达及意义。方法:采用FQ-PCR法检测94例PTC及癌旁组织,29例甲状腺腺瘤组织中PTEN mRNA和Smad4 mRNA的表达情况。结果:PTC高、中、低转移变型组PTEN mRNA和Smad4 mRNA的表达明显低于甲状腺腺瘤组及癌旁组,差异具有统计学意义(P<0.05);且PTEN mRNA表达与Smad4 mRNA表达呈正相关(P<0.05)。结论:PTEN和Smad4在PTC的发生发展过程中存在协调关系,二者的低表达可作为判断PTC预后不良的指标。Objective：To study the expression and clinical significance of PTEN mRNA and Smad4 mRNA in papillary thyroid carcinoma（PTC）.Methods：Real-time fluorescence quantitative polymerase chain reaction（FQ-PCR）was used to detect the expression of PTEN mRNA and Smad4 mRNA in 94 cases PTC and para-carcinoma tissues,and 29 cases thyroid adenoma tissues.Results：The expression of PTEN mRNA and Smad4 mRNA were significantly lower in high,moderate and low-metastases PTC groups compared with thyroid adenoma and para-carcinoma tissues（P0.05）.There had positive relationships between PTEN mRNA expression and Smad4 mRNA expression（P0.05）.Conclusions：There has synergistic relationship between PTEN and Smad4 during development of PTC,their lower expression can be the index to judge unfavourable prognosis of PTC.

关 键 词：甲状腺乳头状癌 PTEN MRNA SMAD4 MRNA 实时荧光定量聚合酶链反应 

分 类 号：R736.1[医药卫生—肿瘤]