子宫富于细胞型平滑肌瘤中β-catenin表达的病理特征分析与探讨  

Analysis and Discussion the Pathological Features of β-catenin which Rich in Uterine Smooth Muscle Tumor Cell

作　　者：曾洲红 朱秀梅 罗卫 袁夏华 

机构地区：[1]广东省高州市人医院病理科,广东高州525200

出　　处：《中国医药指南》2012年第14期37-38,共2页Guide of China Medicine

摘　　要：目的分析与探讨β-联蛋白(β-catenin)在子宫富于细胞型平滑肌瘤中的表达及意义。方法采用免疫组织化学SP染色法对20例普通型平滑肌瘤,36例富于细胞型平滑肌瘤、10例正常子宫肌壁及2例子宫内膜间质肉瘤的β-catenin表达水平进行检测。结果β-catenin在子宫富于细胞型平滑肌瘤的细胞浆内表达,其阳性率高于普通型子宫平滑肌瘤和子宫肌壁平滑肌细胞(P<0.001)。结论β-catenin的表达可能与子宫富于细胞型平滑肌瘤的生物学行为有关。细胞浆内β-catenin蛋白表达有助于普通型子宫平滑肌瘤、富于细胞型平滑肌瘤及子宫内膜间质肉瘤之间的鉴别诊断。Objective Analysis and discussion the pathological features of β-catenin which rich in uterine smooth muscle tumor cell. Methods The immunohistochemical SP staining in 20 cases of common type leiomyoma, 36 cases of smooth muscle cell rich tumor, 10 cases of normal uterine muscle wall, and 2 cases of endometrial stromal sarcoma of the β-catenin expression levels were detected. Results β-catenin expression may be associated with uterine smooth muscle cell rich biological behavior of tumor. Conclusion β-catenin expression may be associated with uterine smooth muscle cell rich tumor biological behavior. Cytoplasm β-catenin protein expression contributes to common type of uterine leiomyoma, smooth muscle cell rich tumor and between endometrial stromal sarcoma in the differential diagnosis.

关 键 词：子宫富于细胞型平滑肌瘤 Β-CATENIN 免疫组织化学 鉴别诊断 

分 类 号：R737.33[医药卫生—肿瘤]