PPARγ功能与疾病关系研究进展  

Function of PPARγ and its relationship with diseases:a present review

作　　者：马晶晶[1] 章涛[1] 

机构地区：[1]遵义医学院附属医院贵州省细胞工程重点实验室,贵州遵义563003

出　　处：《中国药理学通报》2012年第5期601-604,共4页Chinese Pharmacological Bulletin

基　　金：贵州省科学技术基金项目(No 黔科合J字2008-2152号)

摘　　要：过氧化物酶体增殖物激活受体γ(peroxisome prolifera-tor-activated receptor gamma(PPARγ)对脂质代谢、脂肪形成、细胞分裂和凋亡等多种生物学过程具有调节作用。近年来的研究发现,配体激活PPARγ具有抗肥胖、高血压、动脉粥样硬化、糖尿病、肿瘤等疾病的有益作用,使得围绕PPARγ受体功能和配体筛选研究成为生物医学和药理学研究的前沿热点,并有望成为治疗上述顽疾的新的药物靶标。该文就PPARγ与疾病关系的研究进展做一综述。Peroxisome proliferator-activated receptor γ（PPARγ） plays important roles in regulation of diverse biological process such as lipid metabolism,adipogenesis,cell division and apoptosis.Recent studies have shown that ligand activated PPARγ bring beneficial effects on diseases including obesity,hypertension,atherosclerosis,diabetes mellitus,tumor,etc.Consequently,the studies encompassed PPARγ function and its ligands screening have become a hotspot in biomedicine and pharmacology,PPARγ is expected to become a new treatment target of the above diseases.This review focus on discussion the function of PPARγ and its relationship with diseases.

关 键 词：过氧化物酶体增殖物激活受体Γ 肿瘤 动脉粥样硬化 肝纤维化 肾脏疾病 神经保护 

分 类 号：R-05[医药卫生] R392.11