辛伐他汀对厄贝沙坦药代动力学影响的研究  

The influence of simvastatin on the pharmacokinetics of irbesartan in rabbits

作　　者：周霞瑾[1] 齐惠珍[1] 牛哲哲[1] 王明霞[1] 常青[2] 

机构地区：[1]河北医科大学第四医院药剂科,河北石家庄050011 [2]河北医科大学药学院,河北石家庄050017

出　　处：《中国药理学通报》2012年第5期701-704,共4页Chinese Pharmacological Bulletin

基　　金：河北省卫生厅"2010年度医学科学研究重点课题计划"项目(No 20100443;20100122);河北省人力资源和社会保障厅留学回国人员科技活动择优资助项目(No 20100313)

摘　　要：目的探讨辛伐他汀相同剂量(5 mg·kg-1)诱导不同时间(3 d和5 d)对新西兰大白兔体内厄贝沙坦药代动力学的影响。方法 24只新西兰大白兔随机分为4组,分别是:3 d对照组(以2%羧甲基纤维素溶液为对照,单用厄贝沙坦50 mg·kg-1)、5 d对照组(以2%羧甲基纤维素溶液为对照,单用厄贝沙坦50 mg·kg-1)、辛伐他汀3 d和辛伐他汀5d诱导组。采用HPLC-荧光法测定血药浓度,DAS3.0软件进行数据处理,计算药代动力学参数。Cmax和Tmax为实验测得。主要药代动力学参数用SPSS13.0软件包进行统计分析。结果经统计分析,与相应对照组比较,辛伐他汀3 d诱导组厄贝沙坦在兔体内的主要药代参数如AUC、CL、Cmax、T 12等差异无显著性(P>0.05);而辛伐他汀5 d诱导组的主要药代参数AUC(0-36)、AUC(0-∞)、MRT(0-36)、MRT(0-∞)、Cmax明显增加(P<0.05),CL明显降低(P<0.05);辛伐他汀5 d诱导组与辛伐他汀3 d诱导组相比,其主要药代参数AUC(0-36)、AUC(0-∞)、MRT(0-36)、MRT(0-∞)、Cmax增加(P<0.05),CL降低(P<0.05)。结论辛伐他汀诱导3 d对新西兰大白兔体内厄贝沙坦的药代动力学无影响;辛伐他汀诱导5 d明显影响新西兰大白兔体内厄贝沙坦的药代动力学;与辛伐他汀3 d诱导组比,辛伐他汀5 d诱导对新西兰大白兔体内厄贝沙坦的药代动力学影响明显。Aim To investigate the effect of simvastatin on pharmacokinetics of irbesartan after oral administration of simvastatin 5 mg·kg-1 for 3 days and 5 days respectively.Methods 24 New Zealand white rabbits were divided into 4 groups,randomized as follows：control（3 days）,control（5 days）,simvastatin for 3 days group and simvastatin for 5 days group.The concentrations of irbesartan were determined by HPLC-fluorescence method.The results of the plasma samples were analysed with the DAS version 3.0（Bontz Inc.,Beijing,China） program to determine the compartment models and the pharmacokinetic parameters,and the statistics were analysed by SPSS 13.0 program.Results Compared with the correspond control,there was no obvious influence on the pharmacokinetic parameters of irbesartan such as AUC,CL,Cmax,T1 2 et al.（P0.05） after inducing with simvastatin（5 mg·kg-1） for 3 days;compared with the correspond control,inducing with simvastatin（5 mg·kg-1） for 5 days,the major pharmacokinetic parameters such as AUC（0-36）,AUC（0-∞）,MRT（0-36）,MRT（0-∞）,Cmax were increased obviously（P0.05）,and CL decreased obviously（P0.05）;simvastatin inducing for 5 days compared with simvastatin inducing for 3 days,the major pharmacokinetic parameters such as AUC（0-36）,AUC（0-∞）,MRT（0-36）,MRT（0-∞）,Cmax were increased obviously（P0.05）,and CL decreased obviously（P0.05）.Conclusions There is no significant influence on the pharmacokinetics of irbesartan after inducing with simvastatin（5 mg·kg-1） for 3 days.There is significant influence on the pharmacokinetics of irbesartan after inducing with simvastatin（5 mg·kg-1） for 5 days.Simvastatin（5 mg·kg-1） inducing for 5 days compared with simvastatin（5 mg·kg-1） inducing for 3 days,there is significant influence on the pharmacokinetics of irbesartan.

关 键 词：厄贝沙坦 辛伐他汀 血药浓度 药代动力学 HPLC-荧光法 CYP3A4 CYP2C9 P-gp 

分 类 号：R-332[医药卫生] R969.1