益生菌与结直肠癌发病的关系  

Probiotics and Colorectal Tumorigenesis

作　　者：杨静[1] 朱元民[1] 刘玉兰[1] 

机构地区：[1]北京大学人民医院消化内科,100044

出　　处：《胃肠病学》2012年第4期242-244,共3页Chinese Journal of Gastroenterology

摘　　要：肠道菌群与人体健康有密切联系,炎症性肠病、结直肠癌等均与肠道菌群失调有关。摄入益生菌制剂是调节肠道菌群及其功能较为常用的方法。研究表明补充益生菌可能通过调节肠道黏膜免疫和炎症、抑制致病菌定植和繁殖、修复肠上皮屏障功能、抑制肿瘤细胞增殖、抑制致癌化学物活性以及抗氧化作用等,对结直肠肿瘤产生一定预防和治疗作用。本文就益生菌与结直肠癌发病的关系作一综述。Gut microbiota impacts human health profoundly and it is demonstrated that a composition change in microbiota could be associated with various disorders such as inflammatory bowel disease and colorectal cancer. Intake of probiotic formulations is a popular approach to modulate the microbiome and its functions. In fact, there is growing evidence that probiotics supplement is a potential approach to prevent and treat colorectal neoplasms, and the antitumor effect might be attributed to multifactorial mechanisms, including modulation of intestinal mucosal immune responses and inflammation, inhibition of colonization and reproduction of pathogenic bacteria, restoration of intestinal epithelial barrier function, inhibition of tumor cell proliferation, repression of carcinogenic chemicals, increase of antioxidant potential, etc. We summarized the relationship between probiotics and coloreetal tumorigenesis in this review article.

关 键 词：益生菌 结直肠肿瘤 肠道菌群 炎症 

分 类 号：R735.3[医药卫生—肿瘤]