ALL-2005方案对儿童急性淋巴细胞白血病髓外白血病防治效果分析  

Analysis of prevention and therapeutic effectiveness of extramedullary leukemia in children with childhood acute lymphoblastic leukemia with ALL-2005 protocol

作　　者：薛惠良[1] 汤静燕[1] 陈静[1] 潘慈[1] 周敏[1] 董璐[1] 汤燕静 王坚敏 叶启东 顾龙君[1] 

机构地区：[1]上海交通大学医学院附属上海儿童医学中心血液/肿瘤科,上海200127

出　　处：《临床儿科杂志》2012年第5期412-414,共3页Journal of Clinical Pediatrics

摘　　要：目的总结ALL-2005方案对急性淋巴细胞白血病(ALL)患儿髓外白血病,包括中枢神经系统白血病(CNSL)及睾丸白血病(TL)的防治效果。方法 2005年5月—2008年5月共218例ALL患儿,采用ALL-2005方案进行治疗,总结其临床及治疗情况。结果 218例ALL患儿中,5例初诊时伴CNSL,1例于诱导治疗期间发生CNSL,4例于维持治疗期间发生CNSL;1例初诊时伴TL发生,4例维持治疗期间发生TL。经治疗,2例CNSL患儿骨髓复发,其余8例均缓解至今;TL患儿1例骨髓复发,1例放弃治疗,3例缓解至今。结论 ALL-2005方案疗效良好,有利于提高患儿长期生存质量。[临床儿科杂志,2012,30(5):412-414]Objective To analyze the prevention and therapeutic effectiveness of extramedullary leukemia including central nervous system leukemia（CNSL） and testicular leukemia（TL） in children with childhood acute lymphoblastic leukemia（ALL） with ALL-2005 protocol.The clinical data were summarized.Methods From May 2005 to May 2008,218 children with ALL were treated with All-2005 protocol.The clinical data were summarized.Results Five of 218 patients were found with CNSL and 1 with TL at the time of initial diagnosis of ALL.One child developed CNSL during treatment,4 developed CNSL and 4 developed TL during maintenance treatment.After treatment,2 patients with CNSL and 1 patient with TL relapsed;and 8 patients with CNSL and 3 patients with TL have been relieved and 1 patient with TL abandoned treatment.Conclusions ALL-2005 protocol shows good therapeutic effectiveness in treatment of children with ALL and improves the life quality of long term survival.

关 键 词：急性淋巴细胞白血病 髓外浸润 治疗 儿童 

分 类 号：R733.71[医药卫生—肿瘤]