肝星状细胞与肿瘤肝转移的研究进展  

Progression on the relationship between hepatic stellate cell and hepatic cancer metastasis

作　　者：刘虎(综述)[1] 杨家和[1] 苏长青(审校)[2] 

机构地区：[1]第二军医大学东方肝胆外科医院腹腔镜科,上海200438 [2]第二军医大学东方肝胆外科医院分子肿瘤实验室,200438

出　　处：《临床肿瘤学杂志》2012年第4期360-363,共4页Chinese Clinical Oncology

基　　金：国家自然科学基金资助项目(81071866;30872998)

摘　　要：肝脏是人体各类恶性肿瘤易于发生转移的部位,而肝星状细胞(HSC)在肿瘤肝转移中扮演着极为重要的角色。HSC能够促进和构成肿瘤细胞肝转移的微环境,肿瘤细胞又诱导HSC活化,活化的HSC又反作用于肿瘤细胞促其生长,两者双向作用呈现级联扩大效应,最终促进肿瘤侵袭、转移及生长。Liver is an organ that human malignant tumors are easy to metastasize,and the hepatic stellate cells（HSC） play an important role in cancer metastasis.HSC can promote and constitute a microenvironment that is suitable for cancer hepatic metastasis.Moreover,cancer cells can also induce activation of HSC and the activated HSC makes a feedback reaction to promote cancer growth,which constitutes a cascade ampliative efficacy and finally accelerates cancer infiltration,metastasis and growth.

关 键 词：肝脏 肿瘤 肝转移 肝星状细胞 微环境 

分 类 号：R735.7[医药卫生—肿瘤]