平卧菊三七叶化学成分的分离与鉴定  

Isolation and identification of chemical constituents from leaves of Gynura procumbens(Lour.)Merr.

作　　者：张颖[1,2] 姜坤[2] 杨利军[2] 谭俊杰[2] 孟大利[1] 谭昌恒[2] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]中国科学院上海药物研究所天然药物化学研究室,上海201203

出　　处：《沈阳药科大学学报》2012年第5期337-339,共3页Journal of Shenyang Pharmaceutical University

基　　金：国家"重大新药创制"科技重大专项资助项目(2009ZX09301-001)

摘　　要：目的研究平卧菊三七叶子的化学成分。方法采用硅胶柱色谱法、反相ODS柱色谱法、Seph-adex LH-20柱色谱法和HPLC法等进行分离纯化,并通过波谱分析技术鉴定其化学结构。结果从平卧菊三七叶子中分离得到7个化合物,分别鉴定为β-谷甾醇-3-O-龙胆二糖苷(β-sitosterol-3-O-gentiobioside,1)、3-吲哚甲酸(indole-3-carboxylic acid,2)、蚱蜢酮(grasshopper ketone,3)、β-谷甾醇(β-sitosterol,4)、毒豆甲酮(drummondone A,5)、正三十二烷醇(n-dotriacontanol,6)和毒豆乙酮(drummondone B,7)。结论化合物1～3、5、7为首次从菊三七属植物中分离得到,化合物4、6为首次从平卧菊三七中分离得到。Objective To study the chemical constituents of leaves of Gynura procumbens(Lour.)Merr.Methods The compounds were isolated by chromatography on silica gel colunm,C18 reversed-phase column,Sephadex LH-20 column and HPLC,and their structures were determined on the basis of spectral analysis.Results Seven compounds were obtained and identified as β-sitosterol-3-O-gentiobioside(1),indole-3-carboxylic acid(2),grasshopper ketone(3),β-sitosterol(4),drummondone A(5),n-dotriacontanol(6),drummondone B(7).Conclusions Compounds 1-3,5 and 7 are isolated from Gynura genus firstly,while compounds 4 and 6 are isolated from Gynura procumbens(Lour.)Merr.for the first time.

关 键 词：平卧菊三七 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学] R284.2[医药卫生—药学]