青春期摄入豆类食品对女性乳腺癌发病影响的系统评价  

Soy Foods Intake in Adolescence and the Risk of Breast Cancer:A Systematic Review

作　　者：赵阳[1] 潘建红[2] 张立力[1] 

机构地区：[1]南方医科大学护理学院,广州510515 [2]南方医科大学公共卫生与热带医学学院生物统计学系,广州510515

出　　处：《中国循证医学杂志》2012年第5期550-556,共7页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价青春期摄入豆类食品对女性成年后乳腺癌发病影响。方法计算机检索Cochrane Library、MEDLINE、EMbase、CNKI、VIP、WanFang Data和CBM中关于青春期食用豆类食品对女性成年后乳腺癌发病影响的队列研究和病例对照研究,同时追索纳入文献的参考文献。文献检索起止时间均为从建库至2011年8月。由两名研究者严格按照纳入和排除标准筛选文献、提取资料,并根据Cochrane协作网推荐的Newcastle-Ottawa scale(NOS)和GRADE系统推荐的分级方法进行质量评价,对符合标准的研究进行Meta分析。最后采用Stata 11.0和GRADE pro ler 3.2.2软件进行统计分析。结果共纳入6个研究,6609例病例和79538例对照。Meta分析结果显示,青春期食用豆类食品较多的女性比青春期不食用或很少食用豆类食品的女性成年后乳腺癌的发病风险低[OR=0.816,95%CI(0.670,0.993)]。亚组分析结果显示,青春期豆类食品的摄入对绝经前乳腺癌的预防作用[OR=0.661,95%CI(0.550,0.796)]强于绝经后[OR=0.782,95%CI(0.486,1.259)];而无论东、西方女性摄入豆类食品均受益[OR=0.793,95%CI(0.569,1.105);OR=0.837,95%CI(0.743,0.943)]。结论青春期食用豆类食品对女性成年后乳腺癌发病可能具有一定的预防作用,且对绝经前乳腺癌的预防作用尤其明显,而无论东、西方女性均受益。受纳入研究数量与质量的限制,上述结论尚需进一步验证。Objective To assess the influence of soy foods intake in Adolescence on the female adult＇s breast cancer.Methods Literatures about the influence of soy foods intake in Adolescence on the female adult＇s breast cancer were retrieved in The Cochrane Library,MEDLINE,EMbase,CNKI,VIP,WanFang Data and CBM from the date of their establishment to August 2011,meanwhile,the references of included papers were also retrieved.The data were extracted according to the inclusion and exclusion criteria by two reviewers independently,the quality of the included studies was assessed according to the Cochrane Newcastle-Ottawa scale and GRAEDprofiler 3.2.2,and meta-analysis was conducted by using Stata 11.0.Results A total of 6 studies involving 6609 patients and 79538 controls were included.The results of meta-analyses showed that compared with the non-intake or low intake of soy foods in Adolescence,high soy foods intake in Adolescence was associated with lower risk of breast cancer（OR=0.816,95%CI 0.670 to 0.993）;In the subgroup analysis,soy foods intake in Adolescence was more effective to prevent premenopausal（OR=0.661,95%CI 0.550 to 0.796） rather than post-menopausal（OR=0.782,95%CI 0.486 to 1.259） breast cancer;and the effects of soy foods intake in Adolescence were not significantly different between the eastern（OR=0.793,95%CI 0.569 to 1.105） and western（OR=0.837,95%CI 0.743 to 0.943） women.Conclusion Soy foods intake in Adolescence may be associated with a small reduction in the risk of adults＇ breast cancer,especially for the premenopausal women,though there is no difference between the eastern and western women.However,restricted by quantity and quality of the studies,this conclusion should be confirmed by more studies.

关 键 词：青春期 豆类食品 乳腺癌 META分析 系统评价 

分 类 号：R737.9[医药卫生—肿瘤]