白细胞介素-6基因174G/C多态性与缺血性脑卒中风险相关性的Meta分析  

Correlation between Interleukin-6 174G/C Polymorphism and Ischemic Stroke:A Meta-Analysis

作　　者：黎炳护[1] 张莉莉[1] 尹延伟[1] 皮燕[1] 杨清武[1] 方传勤[1] 高长越[1] 王景周[1] 李敬诚[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所神经内科,重庆400042

出　　处：《中国循证医学杂志》2012年第5期563-569,共7页Chinese Journal of Evidence-based Medicine

基　　金：国家自然基金(30970998;30800444);重庆市科技攻关计划项目(CSTC2010GGC502)

摘　　要：目的探讨白细胞介素-6(interleukin-6,IL-6)基因174G/C多态性与缺血性脑卒中(ischemic stroke,IS)风险的相关性。方法计算机检索CBM、CNKI、PubMed、MEDLINE和EMbase数据库,收集从建库至2011年8月间关于IL-6基因174G/C多态性与IS风险相关性的病例对照研究,由两名研究者独立进行资料提取、质量评价并交叉核对后,采用RevMan 5.1.2和Stata 11.0软件对符合标准的文献进行Meta分析。结果共纳入12个研究,2537例患者和2767例对照。各遗传模型Meta分析结果显示:IL-6基因174G/C多态性与IS风险的相关性无统计学意义[共显性遗传模型:G/C vs. G/G:OR=0.98,95%CI(0.78,1.24);C/C vs. G/G:OR=0.75,95%CI(0.38,1.50);显性遗传模型:OR=0.93,95%CI(0.68,1.28);隐性遗传模型:OR=0.80,95%CI(0.45,1.42)]。基于人种的亚组分析结果显示两者相关性无统计学意义,而基于对照来源的亚组分析结果显示,对照人群为医院来源的亚组中IL-6基因174G/C多态性是IS的保护因素[共显性遗传模型:G/C vs. G/G:OR=0.56,95%CI(0.40,0.79);C/C vs. G/G:OR=0.17,95%CI(0.11,0.27);显性遗传模型:OR=0.40,95%CI(0.29,0.55);隐性遗传模型:OR=0.24,95%CI(0.16,0.37)]。结论基于目前研究结果显示,IL-6基因174G/C多态性与IS风险无明显相关性。受纳入研究质量和数量限制,上述结论尚待开展更多高质量的前瞻性研究进一步验证。Objective To explore the correlation between interleukin-6（IL-6） 174G/C polymorphism and ischemic stroke risks.Methods Systematic searches of electronic databases as CBM,CNKI,PubMed,MEDLINE and EMbase were performed.Meta-analysis was conducted by using RevMan 5.1.2 and Stata 11.0 software.The pooled odds ratios（ORs） with 95% confidence intervals（95%CIs） were performed.Publication bias was tested by funnel plot,Egger＇s regression test and Begg＇s test.Sensitivity analysis was made by repeating the fixed effects model or random effects model Meta-analysis with each of the studies individually removed.Results A total of 11 publications with 12 studies were identified.The results of meta-analyses showed no significant difference was found in the correlation between IL-6 174G/C polymorphism and ischemic stroke risks（for G/C vs.G/G： OR=0.98,95%CI 0.78 to 1.24;for C/C vs.G/G： OR=0.75,95%CI 0.38 to 1.50;for dominant inheritance model： OR=0.93,95%CI 0.68 to 1.28;for recessive inheritance model： OR=0.80,95%CI 0.45 to 1.42）.In the subgroup analyses on ethnicity,no significant correlation was found.But in the subgroup analyses on source of control population,the hospital-based subgroup showed IL-6 174G/C polymorphism was the protective factor of ischemic stroke（for G/C vs.G/G： OR=0.56,95%CI 0.40 to 0.79;for C/C vs.G/G： OR=0.17,95%CI 0.11 to 0.27;for dominant inheritance model： OR=0.40,95%CI 0.29 to 0.55;for recessive inheritance model： OR=0.24,95%CI 0.16 to 0.37）.Conclusion Meta-analysis strongly suggests that the correlation between IL-6 174 G/C polymorphism and ischemic stroke is not significantly different.

关 键 词：缺血性脑卒中 白细胞介素-6 174G/C 基因多态性 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]