新鲜冰冻血浆治疗遗传性血管性水肿急性发作16例次分析  

Analysis on treating hereditary angioedema acute attack with fresh frozen plasma in 16 case-times

作　　者：汤蕊[1] 陈适[2] 张宏誉[1] 

机构地区：[1]中国医学科学院,北京协和医学院北京协和医院变态反应科,北京100730 [2]中国医学科学院,北京协和医学院北京协和医院内分泌科,卫生部内分泌重点实验室,北京100730

出　　处：《局解手术学杂志》2012年第3期283-284,共2页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨新鲜冰冻血浆(FFP)治疗遗传性血管性水肿(HAE)的适应证、安全性和有效性。方法回顾性分析北京协和医院4例次及文献中12例次共16例次FFP治疗HAE急性发作的病例。结果共13例HAE患者急性期16次输注FFP,输注量平均(586±337)mL,输注后15例次病情得到改善,1例次因输血反应中断用药。症状开始缓解时间为(49±19)min,输注后完全缓解时间由输注前的(6.7±27.0)h缩短为(2.0±12.0)h。除2例次患者出现腹痛加重、1例次患者出现皮疹外,其他患者均未出现不良反应。结论 FFP用于HAE急性发作期治疗相对安全有效。Objective To discuss the indication,safety and efficiency of FFP for the treatment of HAE.Methods Retrospective analyze the clinical data of 2 patients with HAE in Peking Union medical college hospital and 11 patients in the medical literatures.ResultsThirteen cases of patients were injected with FFP totally 16 times,and the average dosage of FFP is（586±337） mL.Only one patient failed to be cured because of transfusion reaction.The symptoms begin to ease（49±19）minutes after injection.And the time of complete remission reduced from（61.7±27.0） hours to（2.0±12.0）hours after FFP injection.There were 2 cases of abdominal pain and 1 case of skin rash,and others have no adverse reaction.Conclusion FFP is safe and effective for acute attacks of HAE.

关 键 词：遗传性血管性水肿 新鲜冰冻血浆 治疗 

分 类 号：R596.1[医药卫生—内科学] R457.14[医药卫生—临床医学]