超声引导经皮门静脉穿刺在干细胞移植治疗失代偿期肝硬化中的应用价值  

Application value of ultrasonic guided percutaneous portal vein punctures on autologous stem cells transplantation for the patients with decompensated liver cirrhosis

作　　者：孙厚坦[1] 杨峰 赵威武[1] 闫保华 陈朝旻[1] 周新人 徐晓燕[1] 滕红[1] 张明立[1] 

机构地区：[1]兰州军区兰州总医院安宁分院影像特诊科,730070 [2]兰州介入超声诊疗技术研究中心 [3]兰州介入超声诊疗技术研究中心感染科

出　　处：《中华超声影像学杂志》2012年第5期397-400,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨超声引导经皮门静脉穿刺自体骨髓干细胞移植对失代偿期肝硬化治疗方法的可行性、安全性及临床疗效。方法对64例肝硬化伴有腹水患者，采用超声引导经皮门静脉穿刺将自体骨髓干细胞植人肝脏，观察临床症状、术后不良反应及肝功能检测结果。结果骨髓干细胞移植后，患者肝功能明显改善，实验室指标均好转，术后不良反应及并发症少，与本院经导管将干细胞植入肝动脉多级分支血管治疗的87例肝硬化患者结果相比较，差异有统计学意义（P〈0．05）。结论超声引导经皮门静脉穿刺干细胞移植治疗肝硬化方法可行，操作简单，安全有效，且副作用小，可作为中晚期肝硬化患者的临床治疗方案。Objective To explore the viability, security and the curative effect of ultrasonic guided percutaneous portal vein puncture on autologous stem cells transplantation for patients with decompensated liver cirrhosis. Methods Sixty-four patients of decompensated liver cirrhosis with ascites were treated by autologous stem cell transplantation through ultrasonic guided percutaneous portal vein puncture. The clinical symptoms after transplantation, postoperative adverse reaction, the results of liver function tests were observed. Results After stem cells transplantation, patients＇ liver function got better obviously, laboratory indicators were better, postoperative adverse reaction and complication were less than those of 87 patients treated with autologous stem cell transplantation into hepatic artery multilevel branch by pipe（ P 〈 0.05）. Conclusions Ultrasound guided percutaneous portal vein puncture on autologous stem cells transplantation is the viability, security, less side effect and effective for treatment patients with decompensated liver cirrhosis. It can be used as the clinical treatment methods for patients with middle-late liver cirrhosis.

关 键 词：超声检查 肝硬化 干细胞移植 

分 类 号：R575.2[医药卫生—消化系统]