小肝癌CT动脉期强化特征与乙酰肝素酶等生物学指标关系的研究  

Small hepatocellular carcinoma：correlation between contrastenhanced CT arterial phase features and bioindicators of heparanase

作　　者：李薇[1] 高剑波[1] 董军强[1] 周悦[1] 郭华[1] 杨学华[1] 

机构地区：[1]郑州大学第一附属医院放射科CT室,河南郑州450052

出　　处：《实用放射学杂志》2012年第5期679-682,共4页Journal of Practical Radiology

基　　金：国家＂十一五＂科技支撑计划课题基金资助项目（编：2007BAI05B05）.

摘　　要：目的 探讨小肝癌动脉期强化特征与相关病理学及生物学指标的关系.方法 回顾性分析经手术病理证实的CT动脉期明显强化与无明显强化的小肝癌病例各35例,对照分析其病理学分级、血管生成情况及乙酰肝素酶（HPA）表达情况.结果 小肝癌CT动脉期明显强化与无明显强化2组间微血管密度（MVD）、HPA表达有统计学意义（P〈0.05）,与病理学分级无统计学意义（P〉0.05）.结论 小肝癌CT动脉期强化水平与其血管生成情况等生物学行为密切相关,可作为诊断及预后判断的有效指标.Objective To investigate the correlation of the performances of contrast-enhanced CT arterial phase with pathological and biological findings in small hepatocellular earcinoma（SFICC）. Methods Totally 70 patients with SHCC approved by surgery and pathology were divided into two groups hased on enhanced level at contrast-enhanced CT arterial phase. The correlation between CT findings pathological characteristics, microvessel density（MVI）） and heparanase（ HPA） expression were analyzed in two groups. Results Both MVD and HPA expression were significantly different（P〈0.05） between the two groups（lesions with obvious enhancement and without enhancement ）. The histological differentiation of SHCC showed no statistical difference with different enhanced CT findings of SHCC （P〉0.05）. Conclusion The enhanced level at contrast enhanced CT arterial phase of SHCC has a closed correlation with angiogenesis condition and the biological findings,and it provided a new clue for evaluating the diagnosis and prognosis of SHCC.

关 键 词：肝脏 肝癌 血管生成 乙酰肝素酶 体层摄影术 X线计算机 

分 类 号：R735.7[医药卫生—肿瘤] R814.42[医药卫生—临床医学]