8-OHdG在医学领域的应用与研究进展  

Medical Application and Research Progress of 8-OHdG

作　　者：朴恩谊[1] 徐立红[1] 

机构地区：[1]浙江大学医学院生物化学与遗传学系,杭州310058

出　　处：《中国细胞生物学学报》2012年第5期493-499,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.20777067)资助项目~~

摘　　要：氧化应激带来的氧化损伤是造成人体多种损伤和病变的重要因素。8-羟基脱氧鸟苷(8-hydroxy-2’-deoxyguanosine,8-OHdG)作为DNA氧化损伤产物是广泛用于研究疾病中氧化损伤机制的关键标志物。国内外大量研究已普遍应用8-OHdG作为分析指标,该文着眼于近年来研究动向,就8-OHdG的作用机理与检测方法,以及职业与环境暴露的危害评价、辅助疾病早期诊断、治疗和新药研发等方面的应用作一综述。Oxidative damages caused by oxidative stress are key factors for a variety of human injuries and diseases. 8-hydroxy-deoxyguanosine （8-OHdG）, a product of oxidative DNA damage, is widely applied in studying the mechanisms of oxidative damage in various diseases. A large number of studies have used 8-OHdG as an analytical indicator. The present paper reviews the recent development of 8-OHdG focusing on its effect mechanisms, detection methods as well as its application in hazard assessment of occupational and environmental exposure, in early diagnosis of disease, and in development of new drugs.

关 键 词：氧化应激 氧化损伤 8-OHDG 

分 类 号：R363[医药卫生—病理学]