理想心血管健康行为和因素对新发缺血性脑卒中的影响  

Relationship between ideal cardiovascular health behaviors and factors with new-onset ischemic stroke

作　　者：王艳秀[1] 吴寿岭[1] 高竞生[1] 郑晓明[1] 安丽杰[1] 田琪[1] 侯国盛[1] 赵海燕[1] 韩艳华[2] 金成[1] 

机构地区：[1]河北联合大学附属开滦医院心内科,河北唐山063000 [2]迁安县人民医院

出　　处：《中华高血压杂志》2012年第4期342-346,共5页Chinese Journal of Hypertension

摘　　要：目的探讨理想心血管健康行为和因素对新发缺血性脑卒中的影响。方法采用前瞻性队列研究方法,以参加2006-07-2007-10开滦集团健康查体的职工为研究对象,排除既往患脑梗死、心肌梗死及与该研究有关的数据和资料不全者,最终91698名职工进入观察队列,观察随访该队列发生新发缺血性脑卒中的情况;依据美国心脏协会定义的理想心血管健康行为和因素,用K-M法计算不同理想心血管健康行为和因素组的缺血性脑卒中累积发病率,并经Log-rank检验;采用Cox比例风险模型分缺血性脑卒中的影响因素。结果具备5～7项理想心血管健康行为和因素的个体只占研究人群的9.1%,其中具备所有7项的只有93例,占研究人群的0.1%,不足4项者占69.4%。具有0～1、2、3、4、5～7项理想心血管健康行为和因素的人群缺血性脑卒中的累积发病率逐渐降低(P<0.01);Cox比例风险模型表明,校正性别、年龄、收入水平、受教育水平后,具备1～6项理想心血管健康行为和因素的人群发生缺血性脑卒中的风险为无健康行为和因素人群的0.99、0.71、0.51、0.35、0.24、0.28倍。结论理想心血管健康行为和因素对脑血管具有保护作用,随着理想心血管健康行为和因素的个数增多,缺血性脑卒中的累积发病率呈下降趋势。Objective To explore the impact of ideal cardiovascular health behaviors and factors on ischemic stroke. Methods Prospective cohort study method was used in our study. 91 698 workers who had participated in the 2006-07-2007-10 Kaiiuan health examination without history of cerebral infarction and myocardial infarction and without data incompleted were recruited. All workers were observed the occurrence of ischemic stroke. According to the AHA definition of ideal cardiovascular health behaviors and factors, the cumulative incidence of ischemic stroke in different groups were calculated with the K-M method, and compared by the Log-rank test; Cox proportional hazards regression was used to calculate hazard ratios and 95 %confidence intervals for baseline health behaviors and factors. Results Only 9. 1% of the study cohort had 5-7 ideal cardiovascular health behaviors and factors. Only 0. 1 %of study cohort （ 93 cases） had all the ideal cardiovascular health behaviors and factors. 69.4 of the study cohort had less than four ideal cardiovascular health behaviors and factors. The cumulative incidence of ischemic stroke according to 0-1, 2, 3, 4, 5-7 ideal cardiovascular health groups were decreased（P〈0.01）; Cox proportional hazards model showed that, adjusting for gender, age, income level, education level, the risk of ischemic stroke of who had 1-6 ideal cardiovascular health behaviors and factors were 0.99, 0.71, 0.51, 0.35, 0.24 and 0.28 times respectively,compared with who had no ideal cardiovascular health behaviors and factors. Conclusion Ideal cardiovascular health behaviors and factors can protect cerebral vessels. The risk of ischemic stroke is reduced with the increase in the number of ideal health behaviors and factors.

关 键 词：理想心血管健康行为和因素 缺血性脑卒中 队列研究 

分 类 号：R743.3[医药卫生—神经病学与精神病学]