银杏叶提取物合并利培酮口腔崩解片治疗精神分裂症的临床研究  

A clinical study of combined utization of ginkgo biloba extract and risperidone orally disintegrating tablets in the treatment of schizophrenia

作　　者：龚飞中[1] 曾骥[1] 余瑞[1] 龚昌群[1] 刘均富[1] 

机构地区：[1]自贡市第五人民医院,四川自贡643000

出　　处：《四川医学》2012年第4期650-652,共3页Sichuan Medical Journal

摘　　要：目的比较银杏叶提取物合并利培酮口腔崩解片与单用利培酮口腔崩解片治疗精神分裂症的疗效及不良反应。方法将符合标准的75例精神分裂症患者分为两组,一组给予银杏叶提取物合并利培酮口腔崩解片治疗(治疗组,n=40),另一组给予利培酮口腔崩解片治疗(对照组,n=35),疗程6周。用简明精神量表(BPRS)在治疗前及治疗1、2、4、6周末评定疗效,用副反应量表(TESS)评定不良反应。结果两组总体疗效有显著差异:银杏叶提取物合并利培酮口腔崩解片治疗组对精神分裂症起效较快,不良反应没有明显增加。但2周后BPRS减分率的改变则无明显差异。结论银杏叶提取物合并利培酮口腔崩解片治疗症精神分裂症较单用利培酮口腔崩解片起效更快,但2周后BPRS减分率差异无统计学意义,可不必继续联合使用银杏叶提取物。Objective To compare clinical efficacy and the side effects between combined utilization of ginkgo biloba extract and risperidone orally disintegrating tablets and only the use of risperidone orally disintegrating tablets in the treatment of schizophrenia.Methods Seventy-five patients with schizophrenia were treated randomly with combined utilization of ginkgo biloba extract and risperidone orally disintegrating tablets or risperidone orally disintegrating tablets only for six weeks,and measured with the brief psychiatric rating scale（BPRS） and treatment emergent symptom scale（TESS） before treatment and 1,2,4,6 weeks after treatment.Results The both programes were different in efficacy,combined utilization of ginkgo biloba extract and risperidone orally disintegrating tablets is more effective than risperidone orally disintegrating tablets only in treating schizophrenia,and the side effects combined utilization of ginkgo biloba extract and risperidone orally disintegrating tablets is no more effective than risperidone orally disintegrating tablets only in treating schizophrenia.Conclusion The therapeutic effect of combined utilization of ginkgo biloba extract and risperidone orally disintegrating tablets take a active part earlier than only the use of risperidone orally disintegrating tablets in the treatment of schizophrenia.however,the reduced rate of BPRS was no significant difference after 2 weeks,it could be necessary to continue the joint use of ginkgo biloba extract.

关 键 词：银杏叶提取物 精神分裂症 利培酮口腔崩解片 BPRS 

分 类 号：R749.3[医药卫生—神经病学与精神病学]