功能性消化不良患者精神心理因素与十二指肠肥大细胞的相关性  

Relationship between psychosocial factors and duodenal mast cells in patients with functional dyspepsia

作　　者：袁海鹏[1,2] 李福康[2] 李改芹[2] 王晓虹[2] 李晓沛[2] 李延青[1] 

机构地区：[1]山东大学齐鲁医院消化内科,济南250012 [2]山东泰安市中心医院消化内科,山东泰安27100

出　　处：《山东大学学报（医学版）》2012年第6期122-124,129,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨精神心理因素和十二指肠黏膜肥大细胞(mast cell,MC)在功能性消化不良(functional dyspepsia,FD)中的作用。方法应用医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)评定焦虑(HADS-A)和抑郁积分(HADS-D),甲苯胺蓝染色计数十二指肠黏膜MC总数及脱颗粒比率。直线相关分析HADS-A、HADS-D与十二指肠黏膜MC的相关性。结果 FD患者HADS-A和HADS-D显著高于对照组(P<0.05),十二指肠黏膜MC显著高于对照组(P<0.01),MC脱颗粒比率显著高于对照组(P<0.001)。HADS-A、HADS-D与十二指肠MC计数、脱颗粒比率呈正相关(P<0.05)。结论 FD患者的精神心理异常,可能与十二指肠黏膜MC的数目及脱颗粒比率增高有关。Objective To explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of func- tional dyspepsia （FD）. Methods The Hospital Anxiety and Depression Scale （HADS） was used to evaluate the psy- chosocial status of FD patients. Mast cell abundance and degranulation rates in the bulb （ D1 ） and second part （D2） of the duodenum were obtained on toluidine blue-stained sections. The relationships among the scores of anxiety （HADS- A） and depression （HADS-D）, the MC counts and MC degranulation rates in D1 and D2 were studied. Results HADS-A and HADS-D scores were significantly higher in FD patients than in controls （P 〈 0.05）. This was also true for duodenal mast cell abundance （P 〈0. 01 ） and degranulation rates （P 〈0. 001 ）. Scores of HADS-A and HADS-D were positively correlated with the duodenal mast cell abundance and degranulation rates. Conclusion The abnormal psy- chosocial status of FD patients is correlated with the increased abundance and degranulation rates of duodenal mast cells.

关 键 词：功能性消化不良 焦虑 抑郁 十二指肠 肥大细胞 

分 类 号：R573.5[医药卫生—消化系统]