孕早期妇女摄入大豆制品不影响甲状腺功能  

Dietary soy consumption during early pregnancy is not associated with the development of thyroid dysfunction

作　　者：李静[1] 滕晓春[1] 王薇薇[1] 陈彦彦[1] 于晓会[1] 王森[1] 李建新[1] 朱琳[1] 李晨嫣[1] 范晨玲[1] 王红[1] 张红梅[1] 滕卫平[1] 单忠艳[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,辽宁省内分泌疾病重点实验室,沈阳110001

出　　处：《中华内分泌代谢杂志》2012年第5期388-391,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：卫生部公益性基金项目（200802008）;中华医学会内分泌学会青年基金项目（10020030225）

摘　　要：抽取沈阳地区孕早期妇女505例，通过问卷方式获得其对富含大豆制品食物的摄入频度及相关背景资料，分组如下：（1）经常摄入组：≥3次／周；（2）一般摄入组：2次／月-3次／周；（3）偶尔摄入组：≤2次／月。采用固相化学发光酶免疫分析法测定血清TSH、FT4，并对其中95名孕妇的尿异黄酮浓度进行了检测。在调查对象中，经常摄人富含大豆制品食物者占18．6％，一般摄入组占62．6％，偶尔摄入者占18．8％。3组在年龄、甲状腺疾病史、家族史、血清兀1。和TSH水平及甲状腺功能紊乱患病率方面差异均无统计学意义。经常摄入组尿中尿大豆苷元、尿染料木黄酮水平高于其他2组，血清FT4、TSH水平与尿异黄酮浓度无显著相关。本研究提示在碘充足地区，孕早期妇女进食富含大豆的食物未影响甲状腺功能。Data were collected through questionnaire from 505 women enrolled during early pregnancy. Based on soy intake frequency, the subjects were divided into three groups： frequent （ three or more times per week）, conventional （ more than twice per month but less than three times per week）, and occasional （ two or fewer times per month）. Serum TSH and FT4 were measured by chemiluminescence immunoassay. The urinary concentrations of two primary isoflavones （daidzein and genistein ） and creatinine were further assessed in 95 subjects from the three groups. The percentages of frequent, conventional, and occasional consumers were 18.6%, 62.6%, and 18.8%, respectively. No difference was found in age, medical records, family history of thyroid diseases, serum FT4, TSH, and prevalence of thyroid dysfunctions among three groups. Both urinary daidzein and genistein levels were significantly higher in the frequent consumers compared with the other two groups. No correlations were found between urinary isoflavone levels and serum FT4 or TSH. These findings suggest that dietary soy consumption during early nregnancv seems not to be associated with the development of thyroid dysfunction

关 键 词：大豆苷元 染料木黄酮 异黄酮 妊娠 甲状腺 

分 类 号：R151[医药卫生—营养与食品卫生学]