食管癌组织MMP-26和MMP-7表达临床意义的研究  

Expressions of MMP-26 and MMP-7 in esophageal cancer tissues and their significance

作　　者：朱志华 赵羽西[2] 邵玲燕 裘兰兰 

机构地区：[1]三门人民医院胃肠外科,浙江台州317100 [2]中国计量学院现代科技学院,浙江杭州310018

出　　处：《中华肿瘤防治杂志》2012年第5期344-346,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:分析食管癌组织MMP-7和MMP-26的表达,探讨其在食管癌发生发展机制中的意义。方法:用免疫组化Envision法,研究食管癌组织MMP-7和MMP-26的表达、相关性及其与临床病理参数的关系。应用SPSS17.0统计软件进行统计分析。结果:在109例食管癌组织中,≥60岁组和<60岁组MMP-26的阳性表达率分别为88.0%(44/50)和25.4%(15/59);Ⅰ～Ⅱ期和Ⅲ～Ⅳ期的阳性率分别为80.0%(40/50)和32.2%(19/59),鳞癌和腺癌阳性率分别为48.4%(30/62)和61.7%(29/47),高中分化腺癌和低分化腺癌中MMP-26的阳性率分别为90.0%(27/30)和11.8%(2/17),高中分化鳞癌和低分化鳞癌中MMP-26的阳性率分别为47.1%(16/34)和50.0%(14/28),阳性表达率与年龄,病理类型、腺癌分化正相关,P<0.01。在109例食管癌组织中,MMP-7表达,鳞癌和腺癌阳性率分别为45.2%(28/62)和59.6%(28/47),Ⅰ～Ⅱ期和Ⅲ～Ⅳ期的阳性率分别为24.0%(12/50)和74.2%(46/59),与临床分期均相关,P<0.01;而与年龄和性别没有相关性。结论:MMP-26与MMP-7表达与食管癌预后相关,检测MMP-26与MMP-7表达有助于临床医师对食管癌生物学行为评估和治疗方案的制定具有一定的参考价值。OBJECTIVE： To analyze the expression of MMP-26 and MMP-7 in esophageal cancer tissues and their significance. METHODS： Immunohistochemistry assay was used to analyze the relationship of MMP-7 and MMP-26 and esophageal cancer. SPSS17.0 was used for the statistics analysis. RESULTS： In the group of more than 60 years old and less than 60 years old, the expressions of MMP-26 were 88.0%（44/50） and 25.4%（15/59）, in stage Ⅰ-Ⅲ and stage Ⅲ --Ⅳ the expressions were 80.0% （40/50） and 32.2 % （19/59）, in squamous carcinoma and adenocarcinoma the expres- sions were 48. 4 % （30/62） and 61. 7 % （29/47）, in high and low differentiation adenocarcinoma the expressions were 90. 0%（27/30） and 11. 8% （2/17）, in high and low differentiation squamous carcinoma the expressions were 47. 1% （16/34） and 50.0% （14/28）, and the expression of MMP-26 was correlated to age, pathology style and differentiation （P〈0.01）o The expression of MMP-7 in squamous carcinoma and adenocarcinoma were 45. 2% （28/62） and 59. 6%（28/47）,in stage Ⅰ-Ⅱ and stage Ⅲ-Ⅳ the expressions were 24.0%（12/50） and 74.2 %（46/59）, which was correlated to clinical staging（P〈0.01）, and not to age and sex. CONCLUSION： The expressions of MMP-26 and MMP-7 are correlated to the prognosis of esophageal cancer, and the detection is good for the treatment and estimation of esophageal cancer.

关 键 词：食管肿瘤 MMP-26 MMP-7 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]